Mupivacaine hydrochloride to stabilize the neuronal membrane, to prevent the occurrence and spread of nerve impulses, and thus local anesthesia.

The rapid metabolism of mepivacaine hydrochloride, only a small part of the anesthetic (5% to 10%) excretion in the urine unchanged. Methapine is not detoxified by circulating plasma esterase because of its amide structure. The liver is the main site of metabolism, more than 50% of the dose as a metabolite is excreted into the bile. Most metabolized mepivacaine may be absorbed in the intestine and then excreted into the urine because only a small fraction is found in the feces.

The main way to excrete is through the kidneys. Most anesthetics and their metabolites are eliminated within 30 hours. It has been shown that hydroxylation and N-demethylation as detoxification play an important role in the metabolism of anesthetics. Three metabolites of mepivacaine have been identified from adults: two phenols are almost completely excreted as glucuronide conjugates, and N-demethylated compounds (2 & apos;, 6 & apos; Oxygen).

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