Propitocaine hydrochloride



Product Name:  Propitocaine hydrochloride 
Other name:  Propitocaine HCl; Prilocaine HCl 
Synonyms: Prilocaine hydrochloride; 2-(Propylamino)-o-propionotoluidide hydrochloride; Alpha-propylamino-2'-methylpropionanilide hydrochloride; Citanest; N-(2-Methylphenyl)-2-(propylamino)-propanamide hydrochloride; N-(a-propylaminopropionyl)-o-toluidine hydrochloride; Prilocaine hydrochloride; Xylonest; ; N-(2-methylphenyl)-N~2~-propylalaninamide hydrochloride (1: 1); Propitocaine HCl 

Prilocaine HCl EINEC No.: 217-244-0 
Prilocaine HCl Assay: 99% 
Prilocaine HCl M. F.: C13H21ClN2O 
Prilocaine HCl M. W.: 256.7716 
Prilocaine HCl Steam pressure: 2.05E-05mmHg at 25 ° C
Prilocaine HCl Catalog: Antibacterial ;local anesthetics
Prilocaine HCl Appearance: White crystalline odorless powder ,taste slightly bitter sour .
Usage:  Local anesthetics, long duration, lower toxicity, chemicals that are also small Suitable for epidural anesthesia, block anesthesia and infiltration anesthesia, etc.  

Propitocaine hydrochloride is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren. In its injectable form, it is often used in dentistry. It is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/prilocaine or EMLA), for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used forintravenous regional anaesthesia.
 
In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia,which may be treated with methylene blue.
 

Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine) and to hydrophobic group (aromatics) on the other sid. The ester can be hydrolysed in plasma by the enzyme pseudocholinesterase into para-aminobenzoic acid. Amide is stable for longer acting and more systemic distribution. Ester types include Procaine (Novocain) Chloroprocaine (Nesacaine), Tetracaine (Pontocaine), Benzocaine,Tetracaine. Amide types include Lidocaine (Xylocaine), Mepivacaine(Carbocaine), Prilocaine (Citanest),Bupivacaine (Marcaine), Etidocaine (Duranest).

Propitocaine HCl Application:

Prilocaine is a local anesthetic of the amino amide type. Prilocaine is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia. 

Local anesthetic is a substance that causes loss of sensation only to the area to which it is applied without affecting consciousness. Most local anesthetics structures have amino-ester or an amino-amide group which are linked to hydrophilic (secondary or tertiary amine). 

The ester can be hydrolysed in plasma by the enzyme pseudocholinesterase into PARA-aminobenzoic acid. Amide is stable for longer acting and more systemic distribution. Ester types include Procaine (Novocain), Chloroprocaine (Nesacaine), Tetracaine (Pontocaine), Benzocaine, Tetracaine. Amide types include Lidocaine (Xylocaine), Mepivacaine(Carbocaine), Prilocaine (Citanest), Bupivacaine (Marcaine), Etidocaine (Duranest). 


What is the difference between the anesthetic intensity of tetracaine hydrochloride powder and lidocaine, procaine and Dimethocain?
 

• Role: local anesthetics. Tetracaine base >tetracaine hcl>lidocaine>lidcaine hcl> benzocaine > procaine>procaine hcl, but the corresponding side effects will also increase.
   
• It's not that the greater the intensity of anesthesia, the better, unless you want to suffer from more side effects. Generally choose the one that suits you.

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