Product Name: Tacrolimus
CAS: 104987-11-3
MF: C44 H69 N O12
MW: 804.02
EINECS: 1308068-626-2
Product Categories: Inhibitors;Active Pharmaceutical Ingredients;Immunosuppressant.;Chiral Reagents;Fujimycin, Prograf;Intermediates & Fine Chemicals;Pharmaceuticals;antibiotic;
Mol File: 104987-11-3.mol

Macrolide antibiotics. Immunosuppressant. The mechanism of action is the same as cyclosporine, which mainly inhibits the synthesis of interleukin-2. Chemicalbook for rejection of organ transplantation. Use a macrolide that binds to FK506 binding protein (FKBP) to form a complex that reduces peptidyl prolyl isomerase activity in T cells.
 

T acrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. Tacrolimus was first extracted from the fermentation broth of Streptomyces tsukuba, a soil microbe found in Tsukuba, Japan.1 The name tacrolimus is derived by taking the 't' for Tsukuba, the name of the mountain where the soil sample was extracted, 'acrol' for macrolide and 'imus' for immunosuppressant.Although structurally unrelated to cyclosporin, tacrolimus shows a similar spectrum of immunosuppressive effects to this agent at the cellular and molecular level. Initial studies indicated that tacrolimus was a powerful immunosuppressant, displaying approximately 100-fold greater in vitro potency than cyclosporin in inhibiting T cell activation. Subsequent in vivo studies have shown tacrolimus to be effective both in suppressing spontaneous and experimental autoimmune disease, and in preventing allograft and xenograft rejection in animal models of organ transplantation.
Initially, tacrolimus was used for systemic immunosuppression of patients who had undergone allograft transplants to stop them from rejecting their new grafts. Soon, however, through the benefit of the serendipity of science, it was noticed that tacrolimus could produce favorable results in skin disorders in some of the patients who had undergone transplantation. The discovery of tacrolimus has thus lead to greater understanding of skin pathology, for example of atopic dermatitis.Subsequently, other topical applications of tacrolimus were reported and the use of this agent in dermatology is gradually expanding.

Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.

1. who are we?
We are based in Hebei, China, start from 2023,sell to North America(30.00%),Northern Europe(15.00%),Central America(10.00%),Eastern Europe(10.00%),Western Europe(8.00%),Southern Europe(8.00%),Mid East(5.00%),South Asia(3.00%),South America(3.00%),Africa(3.00%),Domestic Market(2.00%),Oceania(2.00%),Southeast Asia(1.00%). There are total about 11-50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
Chloronicotinicacid,2 3-Dichloropyridine,Choline glycerophosphate ,Nicotinamide

4. why should you buy from us not from other suppliers?
Hebei Lingding Biotechnology Co., Ltd. has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with meticulous and though services.

5. what services can we provide?
Accepted Delivery Terms: FOB, CFR, CIF, EXW, Express Delivery;
Accepted Payment Currency: USD;
Accepted Payment Type: T/T, MoneyGram, Western Union ,Cash;
Language Spoken :English, Chinese