Puya Supply High Quality Topiramate CAS 97240-79-4 Treatment Of Epilepsy

Product Name:    Topiramate
Synonyms:    2,3:4,5-Bis-O-(1-methylethylidene)--D-fuctopyranose Sulfamate, McN-4853, RWJ-17021-000, Topamax;McN 4853, RWJ 17021, Topamax, 2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate;Topimax;Topiramic acid;1-O-Sulfamoyl-2-O,3-O:4-O,5-O-bis(1-methylethylidene)-β-D-fructopyranose;1-O-Sulfamoyl-2-O,3-O:4-O,5-O-diisopropylidene-β-D-fructopyranose;Topina;2,3:4,5-Di-O-isopropylidene-β-D-fructopyranoside sulfamate
CAS:    97240-79-4
MF:    C12H21NO8S
MW:    339.36
EINECS:    619-263-3
Product Categories:    TOPAMAX;API;APIs;Health & Beauty;Glutamate receptor;Intermediates & Fine Chemicals;Active Pharmaceutical Ingredients;Carbohydrates & Derivatives;Pharmaceuticals;Pharmaceutical raw materials
Mol File:    97240-79-4.mol


Topiramate (the TPM) is a naturally existing monosaccharide D-fructose sulfide, and together with felbamate, lamotrigine and vigabatrin are current several broad-spectrum anti-epileptic drugs with relatively wide clinical application and can be used to control different types of epilepsy with excellent efficacy and pharmacokinetics. But in cases of being applied to children or fast increase of the amount can cause cognitive impairment and neurotoxicity, and easy to trigger kidney stones. In 1980, scientists had first successfully synthesized tipiramate in the laboratory. It had been applied to patients with epilepsy for the first time in 1986. In 1995, it was approved for entering into the market of UK for the first time. Its basic structure is fructopyranose sulfamate. Unlike other kinds of anti-epileptic drug, TPM has various kinds of anti-epileptic mechanisms including blocking the voltage-dependent sodium channels, enhancing the activity of GABA in the location of the γ-aminobutyric acid A (GABAA) receptor as well as blocking the activity of the AMPA glutamate receptor. In addition, there is still mild effect of carbonic anhydrase inhibitors. Europe and the United States had conducted double-blind, placebo-controlled studies and demonstrated that the adjunctive therapy with topiramate has excellent efficacy, safety and is well tolerated in the treatment of various types of refractory epilepsy. Now it has begun with topiramate monotherapy and has also achieved good results with 62% of patients with epileptic seizures disappearing completely. This product is generally used for the adjuvant treatment of antiepileptic drugs and is effective in treating simple and complex seizures as well as systemic tonic-clonic seizures and can also be used for the treatment of infantile spasms. Features of this product include excellent long-term efficacy, no significant resistance as well as being able to be used alone for antiepileptic purpose.

Topiramate CAS 97240-79-4  of Chemical Properties
Melting point     125°C
Boiling point     438.7±55.0 °C(Predicted)
alpha     D23 -34.0° (c = 0.4 in methan ol)
density     1.336±0.06 g/cm3(Predicted)
Fp     9ºC
storage temp.     2-8°C
solubility     DMSO: ~44 mg/mL
form     solid
pka    9.22±0.70(Predicted)
color     white
Water Solubility     9.705g/L(temperature not stated)
Merck     14,9547
EPA Substance Registry System    .beta.-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, 1-sulfamate (97240-79-4)

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.