Anti-Cancer Drug 2.0% BHT/No BHT Everolimus Powder CAS 159351 -69-6

Model NO.
Everolimus
Colour
White
Safety Precautions
Keep Away From Heat and Fire.
Application
Pharmaceutical Intermediates
MW
958.22
Transport Package
25kg/Drum
Specification
99%
Trademark
Shuer
Origin
Wuhan, China
HS Code
300120001
Production Capacity
100tons/Month
Reference Price
$ 9.72 - 10.80
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Product Description

Product Name: Everolimus
Synonym: Anti-Cancer Drug 2.0% BHT/No BHT Everolimus Powder CAS 159351-69-6
CAS: 159351-69-6
MF: C53H83NO14
MW: 958.22
Appearance: White powder
Package: 1kg/ Bag 25kg/drum Or By Request Of Clients
Storage: Cool Dry Place

Everolimus (RAD001) is an orally active derivative of rapamycin that inhibits Ser / Thr kinase mTOR [1]. In sensitive mouse B16/BL6 melanoma (IC50, 0.7 nM) and insensitive human cervical KB-31 (IC50, 1,778 nM), the antiproliferative concentration of everolimus resulted in a total of S6K1 and substrate S6. Dephosphorylation and changes in mobility. 4E-BP1, indicating a decrease in phosphorylation status [2]. Everolimus showed dose-dependent inhibition in total cells and stem cells from the BT474 cell line and primary breast cancer cells, albeit with varying degrees of growth inhibition. Compared with total cells, everolimus had a poor inhibitory effect on stem cell growth at all concentrations tested (P < 0.001). The IC50 values of everolimus against BT474 and primary CSC were 2,054 and 3,227 nM, respectively, or 29 and 21 times the IC50 values of their respective total cells, respectively.


Function:

Everolimus is indicated for the treatment of postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer (advanced HR+ BC) in combination, after failure of treatment . Indicated for the treatment of adult patients with progressive neuroendocrine tumors of pancreatic origin (PNET) with unresectable, locally advanced or metastatic disease. Indicated for the treatment of adult patients with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib. Indicated for the treatment of adult patients with renal angiomyolipoma and tuberous sclerosis complex (TSC), not requiring immediate surgery. Indicated in pediatric and adult patients with tuberous sclerosis complex (TSC) for the treatment of subependymal giant cell astrocytoma (SEGA) that requires therapeutic intervention but cannot be curatively resected.


Associated Conditions:

Heart Transplant Rejection;
Kidney Transplant Rejection;
Liver Transplant Rejection;
Renal angiomyolipoma, tuberous sclerosis complex;
Subependymal giant cell astrocytoma, tuberous sclerosis complex;
Advanced Carcinoid tumor;
Locally advanced gastrointestinal origin Progressive Neuroendocrine Tumors;
Locally advanced lung origin Progressive Neuroendocrine Tumors;
Metastatic gastrointestinal origin Progressive Neuroendocrine Tumors;
Metastatic lung origin Progressive Neuroendocrine Tumors;
Pancreatic origin Progressive Neuroendocrine Tumors;
Refractory Advanced Renal Cell Carcinoma;
Refractory Waldenstrom's Macroglobulinaemia;
Refractory, advanced Breast cancer;
Unresectable gastrointestinal origin Progressive Neuroendocrine Tumors;
Unresectable lung origin Progressive Neuroendocrine Tumors
 



Anti-Cancer Drug 2.0% BHT/No BHT Everolimus Powder CAS 159351-69-6

FAQ
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Huangmei, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.

Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.

Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service.

Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!

Q6: How should I pay?
A: We accept all kinds of payment ways. such as Credit card, Visa, T/T, West union, MoneyGram

Anti-Cancer Drug 2.0% BHT/No BHT Everolimus Powder CAS 159351-69-6 Anti-Cancer Drug 2.0% BHT/No BHT Everolimus Powder CAS 159351-69-6

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