Items |
Specifications |
CAS: | 1613220-15-7 |
Molecular Formula | C 26 H 30 N 4 O 5 S |
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Molecular Weight | 510.605 |
Exact Mass | 510.193695 |
Usage |
Niraparib is an orally active small molecule PARP inhibitor developed by Tesaro to treat ovarian cancer.
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Cells were stimulated with allogeneic mature DCs or PHA in the presence of imatinib mesylate. The drug inhibited T-cell proliferation as a function of concentration. The effects were significant at 0.5 μM imatinib mesylate for the cells stimulated by DCs and at 1.0 μM imatinib mesylate for the cells stimulated with PHA. The IC50 values for imatinib mesylate-inhibited T-cell proliferation stimulated by DCs and PHA were 3.9 μM and 2.9 μM, respectively.