It shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
It blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by it (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Bencaine. At 1 mM, It blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzcaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type. The inhibition of Ca2+ uptake occurres at lower Benzcaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity. |
Density | 1.1±0.1 g/cm3 |
---|---|
Boiling Point | 310.7±15.0 °C at 760 mmHg |
Melting Point | 88-90 °C |
Molecular Formula | C 9 H 11 NO 2 |
Molecular Weight | 165.189 |
Flash Point | 164.2±17.9 °C |
Exact Mass | 165.078979 |
PSA | 52.32000 |
LogP | 1.95 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.555 |
Storage condition | 0-6°C |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
We have special line transportation, or we can give it to your forwarder Our special line transport is to ensure safe delivery to your designated location, can be free of customs clearance(FedEx/EMS/UPS/DHL/TNT)
Quality best,custom first" is what we adhering all the time
We always believe that the customer comes first, your satisfaction is our greatest achievement
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Hebei Congchang Technology Co.LTD We are a company specializing in the production and management of pharmaceutical intermediates and chemical import and export trade. Our company has long-term cooperation with Wuhan Research Institute and various universities and has a complete scientific research system and quality certification system.The company has two pilot production bases, which are mainly engaged in the production of APIs,pharmaceutical intermediates, and the customization of special chemicals. After several years of operation, the products are sold at home and abroad and won numerous praises.In the future operations, we will continue to adhere to the principles of cooperation, keeping promises, sincerity, equality, mutual benefit and mutual benefit, and provide you with high-quality services.
Welcomed the new and old customers advisory purchase.
Why chooese us?
1.Full experience of large numbers containers loading in Chinese sea port.
2.Fast shipment by reputed shipping line.
3.Packing with pallet as buyer's special request.
4.Best service after shipment with e mail.
5.Cargoes together with container sales service available.
6.Full experience for Canada & Japan export
7.Cargoes photo before and after loading into container.
8.Raw materials from Chinese origin.
Packing&Delivery
Packing:
1. Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
Delivery:
1. Stock products are normally shipping within 3 working days.
2. For rush delivery, please contact our sales team for particular arrangement.
Shipping Details:
1. We ship goods via DHL, Fedex, UPS, TNT, China post, NL Post and other couriers, weight from 10g to 1000kg or even bulker.
2. Shipping details & shipping documents will be provided and sent by email.
3. We keep tracking the shippment until clients well received.
4. After years export shipping experience, with professional and experienced cooperated forwarders, we ensure that goods can be delivered in multiple ways safetly and efficiently.
Q1: Can i get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed(Chinese holiday not included)