Isatoic Anhydride; CAS 118-48-9

Colour
Tan
Shelf Life
2-3 Years
Lead Time
5-7 Working Days
Transport
Air/Express/Sea
MOQ
10g
Site Audit
Available
Certificates
ISO9001/SGS
Stocks
in Stock
Package
1kg/5kg/10kg/25kg
Purity
99%
Samples
Available
Transport Package
Drum/Bottle/Bags
Trademark
Yunbang
Origin
China
Reference Price
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Product Description

Isatoic Anhydride;CAS 118-48-9
 
Isatoic Anhydride; CAS 118-48-9
Isatoic Anhydride Chemical Properties
Melting point  233 °C (dec.) (lit.)
Boiling point  290.19°C (rough estimate)
density  1,52 g/cm 3
vapor density  5.6 (vs air)
refractive index  1.5510 (estimate)
Fp  308 °C
storage temp.  Store below +30°C.
solubility  0.3g/l
pka 11.06±0.20(Predicted)
form  Powder
color  Beige to brown
Water Solubility  decomposes
Sensitive  Moisture Sensitive
BRN  136786
CAS DataBase Reference 118-48-9(CAS DataBase Reference)
NIST Chemistry Reference Isatoic anhydride(118-48-9)
EPA Substance Registry System 2H-3,1-Benzoxazine-2,4(1H)-dione (118-48-9)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36-43
Safety Statements  24-26-37
WGK Germany  1
RTECS  DM3100000
F  3
Autoignition Temperature >600 °C
TSCA  Yes
HS Code  29349990
Hazardous Substances Data 118-48-9(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 6400 mg/kg LD50 dermal Rabbit > 2000 mg/kg
Isatoic Anhydride Usage And Synthesis
Chemical Properties BEIGE TO BROWN POWDER
Uses Isatoic anhydride is a potent inactivator of α-chymotrypsin and inactivates stoichiometrically. Isatoic Anhydride is an important compound in the preparation of serine protease inhibitors.
Definition A bicyclic molecule composed of a benzene ring attached at the oand mpositions to a heterocyclic ring. It forms useful anthranilic acid derivatives by reaction with hydrogen.
Preparation Phosphorus tribro mide (0.035 mol) was added to a solution of N-carbethoxy- or N-carbobenzoxy-anthranilic acid (0.1 mol;prepared by coupling anthranilic acid with the corresponding carbalkoxy chloride in the usual way) in anhydrous diethyl ether (100 mL). After 24 h at room temperature, isatoic anhydride had separated as a microcrystalline product. It was collected by filtration, washed with dry diethyl ether, and recrystallized from ethanol. Yield ca. 90%.
Purification Methods Recrystallise it from EtOH or 95% EtOH (30mL/g) or diox ane (10mL/g) and dry it in a vacuum. [Wagner & Fegley Org Synth Coll Vol III 488 1955, Ben-Ishai & Katchalski J Am Chem Soc 74 3688 1952, UV: Zentmyer & Wagner J Org Chem 14 967 1949, Beilstein 27 II 299, 27III/IV 3330.]
 
Isatoic Anhydride; CAS 118-48-9
 
Isatoic Anhydride; CAS 118-48-9 Isatoic Anhydride; CAS 118-48-9 Isatoic Anhydride; CAS 118-48-9
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. ( Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of P harmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

 

Organic Intermediate