use1
One of the most important features of crown ethers is that they can form stable complexes with various metal salts, ammonium salts, and organic cation compounds. Using this property, various salts can be dissolved in organic solvents. Crown ether can chelate cations into the ring, and at the same time it can form complexes due to the outwardly facing organic genes, and it can also be soluble in non-polar organic solvents. At this time, the unsolvated anion exists in the solvent in the form of a naked anion, so it is extremely active. Crown ethers can dissolve alkali metals and organic alkali metal compounds in organic solvents. Therefore, it has found a wide range of applications in organic synthesis, optical resolution, heavy metal chelation, separation, analysis, and physiologically active medicine and biochemistry. For example, as a phase transfer catalyst, many reactions that are difficult to react or even do not occur under traditional conditions can be carried out smoothly. This type of reaction has a fast rate, simple conditions, convenient operation and high yield. For example, the yield of the condensation reaction of benzoin in an aqueous solution is extremely low. If 7% of crown ether is added to the aqueous solution, a 78% yield of benzoin can be obtained. This reaction can also be carried out in benzene (or acetonitrile). Although potassium cyanide is insoluble in benzene, if 18-crown-6 is added, not only the reaction can occur, but the yield can be as high as 95%. Toxicity of 18-crown-6: The oral lethal dose of rats is 300 mg/kg. Irritating to eyes and skin.
use2
Used as a complexing reagent and phase transfer catalyst. It is widely used in the pharmaceutical industry, electronic solid sealant, adhesive production and other fields.
use3
Strong complexing agent for alkali metal ions. Colorimetric determination reagent for the determination of potassium salt in serum. Organic Synthesis. Phase transfer catalyst.
use4
Macrocyclic ether organic compounds. The main uses are high-efficiency phase transfer catalysts for fine organic synthesis, complexing agents, and extractants for separation and extraction of precious metals and rare earth elements. It can be used for ion enrichment, separation and masking in chemical analysis. It can also be used as ion conductive material and liquid crystal display element production material in medicine, biochemistry field and electronic industry.
use5
Used as a metal ion complexing agent