Factory Wholesale Organic Intermediate BMK Pmk Powder High Purity 99% CAS 94-09 Benzocain
Model NO.
94-09
Sample
Avaiable
Transport Package
Various Packaging/According to Your Request
Specification
99%
Trademark
huayiyiyao
Origin
China
Production Capacity
5000kg/Year
Reference Price
$ 54.00 - 72.00
Description
Product Description
Product Description
Benzocain Biological Activity
| Description | Benzocain shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV. | ||||||||||||
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| Related Catalog |
Signaling Pathways
>>
Membrane Transporter/Ion Channel
>>
Sodium Channel
Research Areas
>>
Neurological Disease
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| Target |
IC50: 0.8 mM (Na+ channel)[1]. |
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| In Vitro | Benzocain blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocain concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocain (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocain. At 1 mM, Benzocain blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocain also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type[1]. The inhibition of Ca2+ uptake occurres at lower Benzocain concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity[2]. | ||||||||||||
| In Vivo | A common Benzocain-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents' oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocain spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing[3]. | ||||||||||||
| Solvent |
In Vitro:
DMSO : ≥ 100 mg/mL (605.36 mM) H 2 O : 2 mg/mL (12.11 mM; ultrasonic and warming and heat to 60°C) * "≥" means soluble, but saturation unknown. In Vivo: 1.Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: ≥ 2.5 mg/mL (15.13 mM); Clear solution 2.Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: ≥ 2.5 mg/mL (15.13 mM); Clear solution 3.Add each solvent one by one: 10% DMSO 90% corn oil Solubility: ≥ 2.5 mg/mL (15.13 mM); Clear solution |
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| Solubility |
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| Storage |
4°C, protect from light |
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| Shipping | Room temperature in continental US; may vary elsewhere | ||||||||||||
| SMILES | O=C(OCC)C1=CC=C(N)C=C1 |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 310.7±15.0 °C at 760 mmHg |
| Melting Point | 88-90 °C |
| Molecular Formula | C 9 H 11 NO 2 |
| Molecular Weight | 165.189 |
| Flash Point | 164.2±17.9 °C |
| Exact Mass | 165.078979 |
| PSA | 52.32000 |
| LogP | 1.95 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.555 |
| Storage condition | 0-6°C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Huayi Pharmaceutical Nanjing Co., Ltd. is a high-tech enterprise mainly engaged in the research and development and sales of high-quality drugs, agricultural chemicals, pharmaceutical intermediates and other related products. In terms of analysis and testing equipment, our company has an advanced and complete supporting system, forming an advanced chemical synthesis can quickly meet the personalized and serialized requirements for industrial production.
Our team by senior industry background and rich market experience of doctor, master and other professionals, committed to the relevant enterprises and institutions and research institutions at home and abroad to provide high-quality chemical products, can not only meet such customers special requirements for products, packaging and purity, and can satisfy the test in manufacturing from the mass production at various stages of comprehensive requirements.
Our adhering to the "scientific development, green development, innovation and development" concept of development, customer success as own duty, makes every effort to to offer the best products, quality service to our customers.
Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of "quality first, customer first and credit-based" since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with anirresistible force.
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