Application
1. Hormone Replacement Therapy (HRT): Estetrol is being investigated as a potential component in hormone replacement therapy for menopausal women. It is believed to offer a more natural and selective estrogen option with a potentially improved safety profile compared to other estrogens.
2. Fetal Neuroprotection: Estetrol has shown promising results in protecting the developing fetal brain in cases of fetal distress or compromised blood flow. It has been studied for its potential neuroprotective effects and the prevention of neurological disorders in newborns.
3. Contraception: Estetrol has been explored for its use in contraceptive methods. It has a unique pharmacokinetic profile with a short half-life, making it suitable for daily contraceptive use. Research is ongoing to evaluate its effectiveness and safety as a contraceptive option.
4. Menopausal Symptoms: Estetrol is being investigated for its potential in alleviating menopausal symptoms, such as hot flashes, night sweats, and vaginal dryness. Its selective estrogenic activity may offer a safer and more targeted approach to managing these symptoms.
5. Breast Cancer Research: Estetrol has been the subject of research in breast cancer treatment and prevention. Studies have examined its effects on breast cancer cells and its potential role in hormone-sensitive breast cancer therapy.
6. Developmental Biology Research: Estetrol is also studied in the field of developmental biology to understand its role in fetal development and its impact on various physiological processes during pregnancy.
Melting point | 233-236°C |
Boiling point | 491.9±45.0 °C(Predicted) |
density | 1.343±0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMSO: soluble20mg/mL, clear |
pka | 10.22±0.70(Predicted) |
optical activity | [α]/D +125 to +135, c = 1 in ethanol |
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