Product Name: Pancuronium bromide
Synonyms: 1,1'-(3alpha,17beta-dihydroxy-5alpha-androstan-2beta,16beta-ylene)bis[1-methyl;Vecuronium Bromide EP Impurity B;Resveratrol 3,4’acetic acid [17-acetyloxy-10,13-dimethyl-2,16-bis(1-methyl-1-piperidin-1-iumyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester dibromide;Vecuronium Bromide Impurity 2(Vecuronium Bromide EP Impurity B);1,1'-[3alpha,17beta-bis(acetyloxy)-5alpha-androstane-2beta,16beta-diyl]bis[1-m;16-diyl)bis(1-methyl-ostane-dibromide;2beta,16beta-dipiperidino-5alpha-androstane-3alpha,17beta-dioldiacetatedimetho
CAS: 15500-66-0
MF:
C35H60Br2N2O4
MW:
732.67
EINECS: 239-532-5
Melting point:
215°C
Boiling point:
113 °C25 mm Hg(lit.)
Density:
1.0268
Storage temp.: 2-8°C
Appearance: White Powder
Description:
Pancuronium bromide, a bisquaternary amine and the first steroid N MBA used clinically, was developed by Savege and Hewitt and marketed in 1964. The intubating dose is 0.1mgkg-1, which takes 3-4min to reach its maximum effect. The clinical duration of action of the drug is long, especially in the presence of potent inhalational agents or renal dysfunction, as 60% of a dose of the drug is excreted unchanged through the kidneys. I t is also deacetylated in the liver; some of the metabolites have neuromuscular blocking properties.
Pancuronium does not stimulate histamine release; however, it has direct vagolytic and sympathomimetic effects which may cause tachycardia and hypertension. It slightly inhibits plasma cholinesterase and therefore potentiates any drug metabolised by this enzyme, such as suxamethonium and mivacurium.
Uses:
Pancuronium is a steroid compound that does not possess hormonal activity. It is used in anesthesiology as a myorelaxant, causing prolonged muscle relaxation during surgical interventions of the thoracic and abdominal cavities, in proctology, ophthalmology, orthopedic practice, and in heart surgeries. A synonym of this drug is pavulon.
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Hubei Yuanmeng Biological Technology Co., Ltd.
Room 3820, Building 2, Vanke Golden City, Hongshan District, Wuhan, Hubei, China
Fiona Wei