Prilocaine structure
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Common Name | Prilocaine | ||
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CAS Number | 721-50-6 | Molecular Weight | 220.311 | |
Density | 1.0±0.1 g/cm3 | Boiling Point | 361.6±25.0 °C at 760 mmHg | |
Molecular Formula | C 13 H 20 N 2 O | Melting Point | 37-38ºC | |
MSDS | N/A | Flash Point | 134.3±23.3 °C |
Use of PrilocainePrilocaine is a local anesthetic of the amino amide type.Target: OthersPrilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils L?fgren. In its injectable form (trade name Citanest), it is often used in dentistry. It is also often combined with lido as a preparation for dermal anesthesia, for treatment of conditions like paresthesia. As it has low cardiac toxicity, it is commonly used for intravenous regional anaesthesia (IVRA). In some patients, a metabolite of prilocaine may cause the unusual side effect of methemoglobinemia, which may be treated with methylene blue. Maximum dosage for dental use: 8.0 mg/kg (2.7 mg/lb), with a maximum dose of 500 mg.Eutectic Mixture of Local Anesthetics (EMLA) containing 5% lido and prilocaine in a cream was found to give effective topical analgesia in normal and diseased skin, making it useful for superficial surgery and various other clinical procedures. To be effective, an adequate amount must be applied under occlusion and at the right time before the intervention. |
Prilocaine Descriptions:
Prilocaine is a local anesthetic that is similar pharmacologically to lido. Prilocaine binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns. Prilocaine acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers. Currently, Prilocaine is used most often for infiltration anesthesia in dentistry. Prilocaine is local anesthetic used to numb a person's skin and tissues. This medication is often made available as a cream that is topically applied, but it may also be available in an injectable form, which should always be administered by a specially trained professional. Its effects are not instant, but once a person experiences the associated numbness it may last for hours. Prilocaine is a local anesthetic of the amino amide type first prepared by Claes Tegner and Nils Lö Fgren. In its injectable form (trade name Citanest), it is often used in dentistry. Prilocaine topical is a local anesthetic (numbing medication). It works by blocking nerve signals in your body.Prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum. Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lido but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lido. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed. Prilocaine Applications: Prilocaine topical is a local anesthetic (numbing medication). It works by blocking nerve signals in your body. Prilocaine topical is used to numb the skin, or surfaces of the penis or vagina, in preparation for a medical procedure or to lessen the pain of inserting a medical instrument such as a tube or speculum. Prilocaine Usage And Synthesis: Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lido but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lido. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use . |
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