CAS 1134-47-0 Baclofen
Baclofen powder also known as β-(4-chlorophenyl)-γ-aminobutyric acid (β-(4-chlorophenyl)-GABA), used as a skeletal muscle relaxant. It is primarily used to treat spasticity. It is also used by compounding pharmacies in topical pain creams as a muscle relaxant.
It is a GABA receptor agonist, specifically of the GABAB receptors. Its beneficial effects in spasticity result from actions at spinal and supraspinal sites. It is a derivative of γ-aminobutyric acid (GABA).
A beneficial property of baclofen is that tolerance to its muscle-related therapeutic benefits does not seem to occur to a significant degree - baclofen retains its therapeutic anti-spasmodic effects even after many years of continued use. Newer studies, however, indicate that tolerance may develop in some people receiving intrathecal baclofen treatment.
Function
1).
Bone muscle spasm caused by multiple sclerosis
.
2).
For spasms caused by infectious, degenerative, traumatic, tumor or unexplained spinal cord disease, Such as: spastic spinal paralysis, amyotrophic lateral sclerosis, spinal cord cavitation, transverse myomyelitis, traumatic paraplegia or paralysis, spinal cord compression, spinal cord tumors and motor neuron disease
.
3).
Used for brain-derived muscle spasms, such as: muscle spasms caused by cerebral palsy, infantile cerebral spasm, stroke and cerebral vascular accidents, brain tumors, degenerative encephalopathy, meningitis, and craniocerebral trauma
.
4).
It can also be used for urinary retention caused by external sphincter
.
Application
1. Used for skeletal muscle spasm caused by multiple sclerosis. 2. For spasticity caused by infectious, degenerative, traumatic, tumor or unexplained spinal cord diseases, such as: spastic spinal palsy, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, trauma Paraplegia or paralysis, spinal cord compression, spinal cord tumors, and motor neuron disease.
2. For spasticity caused by infectious, degenerative, traumatic, tumor or unexplained spinal cord diseases, such as: spastic spinal palsy, amyotrophic lateral sclerosis, syringomyelia, transverse myelitis, trauma Paraplegia or paralysis, spinal cord compression, spinal cord tumors, and motor neuron disease.
3. Used for brain-induced muscle spasm, such as: muscle spasm caused by cerebral palsy, pediatric cerebral palsy, stroke and
cerebrovascular accident, brain tumor, degenerative encephalopathy, meningitis, and craniocerebral trauma. 4. It can also be used
for urinary retention caused by external sphincter spasm.
Specification
|
Identification
|
1) IR
|
Complies
|
|
|
2) HPLC
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Complies
|
|
Water
|
≤0.5%
|
0.10%
|
|
Residue on Ignition
|
≤0.2%
|
0.08%
|
|
3) Residual solvents
|
Methanol: ≤0.3%
Acetone: ≤0.5%
Ethanol: ≤0.5%
|
0.12%
0.01%
Not detected
|
|
Assay
|
99.0~101.0% (calculated on anhydrous
and solvent free basis)
|
99.95%
|
|
Conclusion
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The batch conforms to
USP39
standard requirements
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