Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic

acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA

in their bile; UDCA and conjugates comprise about 47% of the bile in American black bears and up to 76% in Asiatic

bears. TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. 

The chemical name of taurine ursodeoxycholic acid (TUDCA) is 3α, 7β dihydroxycholanoyl-N-taurine, which is a

shrinkage between the sulfo group of ursodeoxycholic acid (UDCA) and the amino group of taurine. Combining bile

acids. TUDCA was found in bear bile in 1902, which is the main bile acid in bear bile, and has antispasmodic,

anticonvulsant, anti-inflammatory, and gallstone dissolving effects. It is mainly used in clinical applications.
 

Application&Function

1. TUDCA Can increase the secretion of bile acid.

2. TUDCA Reduce cholesterol in bile and cholesterol ester.

3. TUDCA Is conducive to the cholesterol gradually dissolve gallstones.

Noticed: TUDCA Should not be used for surgical treatment of cholesterol stone, it cannot dissolve the bile pigment

stone, mixing and opaque X line of stones.