What's Nicotinamide Mononucleotide (NMN) Powder?

Nicotinamide mononucleotide β- Nicotinamide mononucleotide (NMN) is the synthetic substrate of coenzyme I, and NMN is also used in anti-aging research. Research shows, β- NMN can also regulate insul** secretion and affect mRNA expression, β- NMN has a broad application prospect in the field of medical treatment.

β- Nicotinamide mononucleotide is the product of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+intermediate. It improves glucose tolerance by restoring NAD+levels in HFD induced T2D mice. It also enhances insul** sensitivity in the liver and partially restores gene expression related to oxidative stress, inflammatory response and circadian rhythm through SIRT1 activation.

Function of  Nicotinamide Mononucleotide (NMN) Powder:

In mammals, β- Nicotinamide mononucleotide is generated by nicotinamide (Nam) under the catalysis of Nampt (a protease in vivo), and then nicotinamide mononucleotide is generated into NAD+under the catalysis of nicotinamide mononucleotide adenosyltransferase. Nicotinamide mononucleotide is a direct way to supplement NAD+. Nicotinamide mononucleotide has finally achieved the effect of reversing aging by significantly improving the repair ability of DNA damage in cells.

Nicotinamide mononucleotide will be converted into "nicotinamide adenine dinucleotide (NAD)", which is essential for energy metabolism in the body. In mouse experiments, it was confirmed that nicotinamide mononucleotide can activate a gene called acetylase in the body, so as to play a role in prolonging life and treating diabetes. NAD is a substance that can be generated by the human body. Studies have confirmed that the content of NAD in the body will decrease with the increase of age.

Application   of  Nicotinamide Mononucleotide (NMN) Powder:

1. β- Nicotinamide mononucleotide is the precursor of the cofactor NAD+of human longevity protein. NAD+is an important coenzyme of the tricarboxylic acid cycle, which promotes the metabolism of sugar, fat and amino acids, and participates in energy synthesis; NAD+is the only substrate of coenzyme I consuming enzyme (the only substrate of DNA repair enzyme PARP, the only substrate of long-lived protein Sirtuins, and the only substrate of cyclic ADP ribose synthase CD38/157).

2. NAD+participates in all aspects of human metabolism. It is a key chemical book coenzyme. Without NAD+, metabolism will not work. The elderly lack NAD+, so there are various problems, large and small. By adding NAD+, they can fight against aging comprehensively.

3.Pre clinical studies have shown that NMN has a variety of pharmacological activities in heart and brain ischemia, Alzheimer's disease, type 2 diabetes and obesity caused by diet and age. As a precursor of NAD+, NMN mainly synthesizes NAD+in vivo to play a pharmacological role, all of which are related to the lack of NAD+.

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