Chemical Properties
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white crystalline powder
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Uses
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2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
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Definition
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ChEBI: A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group.
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Biological Functions
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Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease.
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Purification Methods
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The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.]
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