Octreotide belongs to digestive system medicine, is a kind of synthetic octapeptide cyclic compound, is the homologue of natural somatostatin, has the pharmacological activity of natural somatostatin (Somatostatin), and has long-acting effect (the half-life of this product is 1.5 hours, while natural somatostatin is 2 to 3 minutes). This product has a selective inhibitory effect on the secretion of glucagon and is stronger than natural somatostatin. Animal experiments have proved that: intravenous injection of this product for 15 minutes can inhibit the release  for natural growth. 70 times that of somatostatin, and the inhibition of is 3 times that of natural somatostatin. It also has inhibitory effect on thyrotropin, adrenocorticotropic hormone, gastrin, cholecystokinin, intestinal vasoactive polypeptide, and can inhibit the secretion of gastric acid, pancreatic amylase, lipase and pepsin. It can slow down the passage time of the gastrointestinal tract, promote the absorption of water and electrolytes, have a contraction effect on visceral blood vessels, reduce visceral blood flow, reduce liver blood flow, reduce portal pressure and portal blood flow, and reduce intestinal excess Secreted, and can enhance intestinal absorption of water and Na+.

The 1st, 4th, and 8th amino acids in the chemical structure of this product are unnatural amino acids, so they are not easily damaged by enzymes and have a longer half-life. Subcutaneous injection of this product is rapidly and completely absorbed, the time to peak plasma concentration is 0.5 hours, the volume of distribution is 0.27L/kg, the half-life is 1.5 hours, and the metabolic clearance rate is 160ml/min. Intravenous injection was biphasic elimination, half-life α-phase and β-phase were 10 minutes and 90 minutes. The plasma protein binding rate is 65%.

Clinically, octreotide is mainly used for the treatment of esophageal variceal worms caused by portal hypertension, acromegaly, gastrointestinal bleeding such as liver cirrhosis, esophageal variceal bleeding, peptic ulcer bleeding and stress ulcer bleeding, pancreatic diseases such as severe Acute pancreatitis, pancreatic injury or postoperative pancreatic fistula, and prevention of complications following pancreatic surgery. Also used for gastrointestinal fistula, digestive endocrine tumors such as intestinal vasoactive peptide tumors, gastrinomas, glucagonomas, ectopic syndrome, carcinoid syndrome, acromegaly, exophthalmos hyperthyroidism persistent, intractable diarrhea and AIDS-associated diarrhea after total colectomy. Intrathecal injections are used to treat cancer pain.

Product Usage: