Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399 -41-7 with Fsat Delivery

Model NO.
Diltiazem Powder cas 42399-41-7
Processing Time
Within 24 Hours After Payment
Best & Competitive Price
Raw Materials From Chinese Origin
We Can Ship
25-500kg to Europe
MOQ
1kg
Type of Packaging
1kg or 5kg/Bag, 25kg/Drum(Safe Cleanence)
Quantity
Multiple Products
Customs Issues
100% No Customs Issues
Export Market
Global (Safe Clearance)
Transport Package
Bag
Specification
1kg/10kg Bag
Trademark
LIKES
Origin
China
Production Capacity
5000kg/Month
Reference Price
$ 10.80 - 15.30
Contact Us

Product Description

Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery

Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery
 

 HeBei LIKES technology Co., Ltd.  is a chemical enterprise full of vitality, potential and comprehensive strength. And it is located in the capital of HEBEI.

Over 10 years of experience working with brand,  we know exactly quality and service is important  to our customers in the chemical industry.  For the last 10 years, this is always the value we believed in .

We are a professional manufacturer engaged in the  research, development, production, sales and service of surfactants, biological agents, organic chemistry, oilfield chemicals and disinfectant raw materials . We can offer a wide range of products of to meet the changing needs of the market, especially engaged in the European and American market.

We can offer different standard  PRODUCTS , for you .
Also we guarantee that our products will be delivered to you in time.
Last but no least,we aim to exceed expectations through consistently providing quality and value in our products and services.

Product Description

Product Name Diltiazem
cas no. 42399-41-7
Other Name Coras;Adizem XL;TILDIEM300LP;Diltiazem;DILTIAZEN;
Density 1.3±0.1 g/cm3
Boiling Point 594.4±50.0 °C at 760 mmHg
Molecular Formula C 22 H 26 N 2 O 4 S
Molecular Weight 414.518
Flash Point 313.3±30.1 °C
Exact Mass 414.161316
PSA 84.38000
LogP 3.63
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.621

Diltiazem is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. Its pharmacological activity is somewhat similar to verapamil, another nondihydropyridine (non-DHP) calcium channel blocker.Chemically, it is based upon a 1,4-thiazepine ring, making it a benzothiazepine-type calcium channel blocker.
It is a vasodilator of coronary and peripheral vessels, which reduces peripheral resistance and afterload, though not as potent as the dihydropyridine (DHP) calcium channel blockers. This results in minimal reflexive sympathetic changes.
Diltiazem has negative inotropic, chronotropic, and dromotropic effects. This means diltiazem causes a decrease in heart muscle contractility - how strong the beat is, lowering of heart rate - due to slowing of the sinoatrial node, and a slowing of conduction through the atrioventricular node - increasing the time needed for each beat. Each of these effects results in reduced oxygen consumption by the heart, reducing angina symptoms. These effects also reduce blood pressure by causing less blood to be pumped out.
 

diltiazem hydrochloride Biological Activity

Description Diltiazem hydrochloride is a Ca2+ influx inhibitor (slow channel blocker or calcium antagonist).
Related Catalog
Signaling Pathways   >>   Membrane Transporter/Ion Channel   >>   Calcium Channel
Research Areas   >>   Cardiovascular Disease
In Vitro Benzothiazepine Ca2+ antagonist diltiazem hydrochloride interacts with transmembrane segments IIIS6 and IVS6 in the α1 subunit of L-type Ca2+ channels[1]. Diltiazem causes a dose-dependent inhibiton of contractions as well as Ca2+ influx stimulated by alpha adrenoceptor activation and high-K+ depolarization. Diltiazem is roughly equally potent in inhibiting contractions induced by high-K+ and a low concentration of norepinephrine (NE)[2]. Diltiazem also inhibits the Na-dependent Ca-efflux from heart mitochondria. Both the (+)-optical isomers of the cis- and trans-forms of diltiazem inhibit Na-Ca exchange activity with comparable potency (IC50 of 10-20 μM)[3].
In Vivo Diltiazem produces a noncompetitive inhibition of Ca2+-induced contractions of depolarized rabbit aorta. Furthermore, there is a lack of parallelism between the smooth muscle effects of removal of [Ca2+]ex and of addition of diltiazem[2]. Diltiazem improves the cardiac microcirculation and function in an experimental model of hyperthyroidism in rats. The treatment of hyperthyroid rats with losartan diltiazem (4.7±0.7%; P < 0.001) significantly reduces the percentage of fibrosis areas in the left ventricle [4]. In conscious spontaneously hypertensive rats (SHR), diltiazem dose-dependently decreases the blood pressure and increases the heart rate after intravenous administration (0.03--1 mg/kg). Oral administration of diltiazem (100 mg/kg) also reduces the blood pressure of SHR[5].
Solvent
In Vitro:

H 2 O : 33.33 mg/mL (73.91 mM; Need ultrasonic)

Solubility
1 mM 2.2174 mL 11.0870 mL 22.1739 mL
5 mM 0.4435 mL 2.2174 mL 4.4348 mL
10 mM 0.2217 mL 1.1087 mL 2.2174 mL
Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
SMILES CN(C)CCN1C2=CC=CC=C2S[C@@H](C3=CC=C(OC)C=C3)[C@@H](OC(C)=O)C1=O.Cl
References

 

 
Product Name   Diltiazem Powder cas  42399-41-7
CAS NO.   Diltiazem Powder cas  42399-41-7
Appearance  powder
Purity 99.9%
Country of Origin China
Certification GMP, ISO 9001, USP
Safe Delivery YES
Application Pharmaceutical raw materials; pharmaceutical intermediates; endrine and hormones; organic intermediates; chemical raw materials
Chemical structure  
Usage Used for product processing and production
Used for factory product processing
Storage Normal Temperature

 

 


Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery
Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery
Advantages
Payment method T/T,L/C
Certification BP,ISO9001,USP,GMP
Customs issues 100% No customs issues
Supply capacity 10000kg/month
Packing

1kg/aluminum foil bag,25kg/cardboard drum
or as customers'request

Transportationg DHL,Fedex,EMS,HKETK,UPS
Delivery time Within 24 hours after payment
Arrival time Within 12-15 days
Factory Address hebei,China
Factory scale 2000-4000 square meters
Staff member above 50 people
QC personnel 20people
RD personnel 10 people
Production line above 10
Export rate above 90%
Export market Global
Terms of Delivery FOB
Payment currency US dollar,Euro

Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery

 

Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery

 

 

Trade Capacity

International Commercial Terms(Incoterms):
FOB, Others
Terms of Payment:
T/T L/C OTHERS
Average Lead Time:
Peak Season Lead Time: within 15 workdays, Off Season Lead Time: within 15 workdays
Number of Foreign Trading Staff:
11~20 People
Export Year:
2012-06-01
Export Percentage:
>90%
Main Markets:
North America, South America, Eastern Europe, Southeast Asia, Africa, Oceania, Mid East, Eastern Asia, Western Europe
Nearest Port:
TIANJIN
SHANGHAI
Import & Export Mode:
Exportation via agency
 


Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery
 

FAQ

Q1: MAY I GET ONE SAMPLE BEFORE PLACING ORDER?
Re: We generally do not provide free product samples before the customer places an order.
But if you need, you just need to bear the freight for normal products; About high value products, you just need to freight and a ite product cost. When we both cooperate for some times or when you are our old customer, free sample will be offered when you need..

2.Q2: WHICH PAYMENT IS AVAIL ABLE FOR YOUR COMPANY?
Re: In order to prompt our cooperation, there are some payment methods for your choice. T/T, Western union,World Remittance, all is ok. You can choose the one which is convenient for you.
Q3: HOW AND WHEN CAN I GET MY GOODS AFTER PAYMENT?
Re: We will send your parcel within 24~48 hours after you pay. We will have a special safe line for transportation to ensure that the package can reach your hand safely. Usually it will cost 3-5 days.

Q4: IS THERE ANY POSSIBLE TO USE MY APPOINTED LABEL OR PACKAGE?
Re: Sure. Our packaging is always safe and concealed. If needed, we'd like to use label or package according to your requirement.

Q5: HOW CAN YOU GUARANTEE THE GOODS YOU OFFER IS QUALIFIED?
Re: Honesty and responsibility are basis of one company, so whatever products we provide for you all are high qualifed. If the goods can't come to the quality we promise, you can ask for resend..

 

 

Packaging & Shipping

Factory Hot Sale 99% Purity Diltiazem Powder CAS 42399-41-7 with Fsat Delivery

Company Profile

Over 10 years of experience working with brand,   we know exactly quality and service is important   to our customers in the chemical industry.   For the last 10 years, this is always the value we believed in .

Our Advantages

1.Rich experience
We are mainly engaged in the European market.Dear Friend,we have been in the European market for 10 years. We will solve two problems for our customers, the first is the customs issue, and the second is the product quality issue.

2.Safest and fastest delivery
Friend,after you paid, pls give us your shipping address, we will send your parcel within 48~72 hours, and give you the tracking number of the parcels. We have cooperating agents in these countries, Our customs clearance company will clear your parcel without customs issues.

3.Good after-sales service.
Best service after shipment . 24-hour Warm after sale service, We will help to solve the problems in your usage.Accept feedback online at any time and provide quality service to our customers.

After Sales Service

Step 1:   Please let me know the items you are favorable, quantities, and the destination country.

Step 2:  You confirm all detail, and offer purchasing order.

Step 3:  We send the detail price of our product and offer the suitable shipping method for reference.

Step 4:  You confirm the order and payment 100% in advance and send us the detailed contacting information, including contacting person/company,address,mobile number,ZIP code and your special requirements.

Step 5:  We arrange the shipment according to your requirements, and tracking code will be offered once it is released , then you can track your parcel at any moment.

Step 6:  We offer after-sales services after service after you receive your parcel.










 

 

Organic Intermediate