Nifedipine; CAS 21829 -25-4

Colour
Yellow
Shelf Life
2-3 Years
Lead Time
5-7 Working Days
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Air/Express/Sea
MOQ
10g
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Package
1kg/5kg/10kg/25kg
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Purity
99%
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Drum/Bottle/Bags
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Yunbang
Origin
China
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Product Description

Nifedipine;CAS 21829-25-4

Nifedipine; CAS 21829-25-4
 
Nifedipine Chemical Properties
Melting point  171-175 °C
Boiling point  481.08°C (rough estimate)
density  1.2109 (rough estimate)
refractive index 
storage temp.  2-8°C
solubility  DMSO: soluble
pka pKa -0.9/>13(DMF,t undefined) (Uncertain)
form  powder
color  yellow
Water Solubility  <0.1 g/100 mL at 19.5 ºC
Merck  14,6528
InChIKey CYCWGQFQPAYBHG-UHFFFAOYSA-N
CAS DataBase Reference 21829-25-4(CAS DataBase Reference)
NIST Chemistry Reference Nifedipine(21829-25-4)
EPA Substance Registry System Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate (21829-25-4)
 
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  26-36
WGK Germany  1
RTECS  US7975000
HazardClass  IRRITANT
HS Code  29333990
Hazardous Substances Data 21829-25-4(Hazardous Substances Data)
Toxicity LD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater)
Nifedipine Usage And Synthesis
Pharmacological effects Nifedipine is a kind of dihydropyridine calcium antagonists, it can inhibit the Ca2 + uptake of cardiac and vascular smooth muscles, and it can expand the coronary artery , increase coronary blood flow,and improve myocardial ischemic tolerance, at the same time, it can expand peripheral arteries and reduce peripheral vascular resistance,and relieve coronary artery spasm, and increase coronary blood flow, improve myocardial ischemia,in order to decrease the blood pressure. Small doses do not affect blood pressure, when expanding coronary artery ,it is a better anti-angina drug .It is used for the prevention and treatment of angina pectoris,with no adverse effects on respiratory function, its efficacy is best particularly for angina pectoris coronary spasm and obstructive airway disease with angina , its efficacy is superior to β-blockers.It is also applied to all types of high blood pressure, including severe and resistant hypertension. Treatment of refractory congestive heart failure may be taking this long. It is also used for the treatment of primary pulmonary hypertension, diffuse esophageal spasm and bronchial asthma, duodenal ulcers, urinary tract obstruction, exercise-induced asthma, achalasia. 
Nifedipine has a certain selectivity on vascular smooth muscles , the direct negative inotropic effect and denaturation effect on the heart are weak, systemic administration of it does not cause the heart rate slowing down ,on the contrary, the heart rate performances reflected increase. 
The above information is edited by the chemicalbook of Tian Ye.
Chemical properties Yellow crystals. Melting point 172-174 ºC. Soluble in ace tone, chlor oform, ethyl ace tate, dissolved in hot meth  anol, insoluble in water. It easily deteriorates in case of light.
Uses Long-term coronary vasodilators. This product can increase coronary blood flow, reducing myocardial oxygen consumption.it is used for acute and chronic coronary insufficiency,especially the angina and myocardial infarction.
Production methods O-nitrobenzaldehyde, methyl acetoacetate, metha nol, amm onia are refluxed together , then froze , crystallize,after filtration, nifedipine crude is obtained . The crude product is recrystallized through met  hanol .then the product is derived , yield rate is 50%.
Category Toxic substances
Toxicity grading Highly toxic
Acute toxicity Oral-rat LD50: 1022 mg/kg; Oral-Mouse LD50: 310 mg/kg.
Flammability and hazard characteristics Combustion produces toxic fumes of nitrogen oxides; medicinal side effects: low blood pressure, cardiac disease, local blood flow disease, high blood sugar, psychosis.
Storage Characteristics Ventilated , low-temperature, drying; and it is kept separately from food raw materials warehouse.
Extinguishing agent Dry powder, foam, sand, carbon dioxide, water spray.
Chemical Properties Yellow Crystalline Solid
Originator Adalat,Bayer,W. Germany,1975
Uses Used as an antihypertensive and antianginal. A dihydorpyri dine calcium channel blocker
Uses Nifedipine is used for preventing and relieving angina pectoris attacks, for hypertension, and as an ingredient in combination therapy for chronic cardiac insufficiency.
Uses For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).
Manufacturing Process 45 grams 2-nitrobenzaldehyde, 80 cc acetoacetic acid methyl ester, 75 cc metha nol and 32 cc ammo nia are heated under reflux for several hours, filtered off, cooled and, after suction-filtration, 75 grams of yellow crystals of MP 172° to 174°C are obtained, according to US Patent 3,485,847.
Brand name Adalat (Bayer); Afeditab (Watson);Procardia (Pfizer).
Therapeutic Function Coronary vasodilator
World Health Organization (WHO) Nifedipine is a dihydropyri dine calcium channel blocker. It is listed in the WHO Model List of Essential Drugs. The 10mg tablet is retained on the list for short-term treatment of hypertension. Sustained-release preparations are advised for long-term treatment.
General Description Nifedipine, 1,4-dihydro-2, 6-dimethyl-4-(2-nitrophenyl)-3,5-pyridi nedicarboxylate dimethyl ester(Adalat, Procardia), is a dihydrop yridine derivative thatbears no structural resemblance to the other calcium antagonists.It is not a nitrate, but its nitro group is essential for itsantianginal effect. As a class, the dihydropy ridines possessa central pyridi ne ring that is partially saturated. To this, positions2 and 6 are substituted with an alkyl group that mayplay a role in the agent's duration of action. In addition, positions3 and 5 are carboxylic groups that must be protectedwith an ester functional group. Depending on the type ofester used at these sites, the agent can be distributed to variousparts of the body. Finally, position 4 requires an aromaticsubstitution possessing an electron-withdrawinggroup (i.e., Cl or NO 2 ) in the ortho and/or meta position.
General Description Odorless yellow crystals or powder. Tasteless.
Air & Water Reactions Aqueous solutions are very sensitive to light. . Insoluble in water.
Reactivity Profile Nifedipine is sensitive to light.
Fire Hazard Flash point data for Nifedipine are not available; however, Nifedipine is probably combustible.
Biological Activity L-type calcium channel blocker.
Mechanism of action Nifedipin causes relaxation of smooth musculature, dilation of coronary and peripheral arteries, and reduction of peripheral resistance and arterial blood pressure, and enhances oxygen supply to the heart.
Clinical Use The prototype of this class, nifedipine, has potent peripheralvasodilatory properties. It inhibits the voltage-dependentcalcium channel in the vascular smooth muscle but has littleor no direct depressant effect on the SA or AV nodes, eventhough it inhibits calcium current in normal and isolated cardiactissues. Nifedipine is more effective in patients whoseanginal episodes are caused by coronary vasospasm and isused in the treatment of vasospastic angina as well as classicangina pectoris. Because of its strong vasodilatory properties,it is used in selected patients to treat hypertension.
Chemical Synthesis Nifedipine, dimethyl ether 1,4-dihydro-2,6-dimethyl-4-(2′-nitrophenyl)-3,5- piridindicarboxylic acid (19.3.16), is synthesized by a Hantsch synthesis from two molecules of a β-dicarbonyl compound-methyl acetoacetate, using as the aldehyde component- 2-nitrobenzaldehyde and amm onia. The sequence of the intermediate stages of synthesis has not been completely established.
 
Nifedipine; CAS 21829-25-4 Nifedipine; CAS 21829-25-4 Nifedipine; CAS 21829-25-4 Nifedipine; CAS 21829-25-4
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. ( Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
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Organic Intermediate