Retinol Cream Anti Aging Remove Wrinkles Facial Cream Hyaluronic Acid Tightening Lifting Neck Night Day Firming Face Cream
Resource
Fermentation
The content of active substances
＞90%
Transport Package
20kg/Carton
Trademark
faithful
Origin
China
HS Code
3913900090
Reference Price
$ 62.10 - 63.90
Description
Product Description
What is Sodium Hyaluronate?
The sources of sodium hyaluronate can be both animal and bacterial. In the past, it was commonly extracted from rooster combs. Still, it is more widely produced through bacterial fermentation, where bacteria are genetically modified to produce high yields of hyaluronic acid.
Sodium hyaluronate has many uses in the medical field and cosmetics. In medicine, it is used to treat joint disorders such as osteoarthritis, as well as for eye surgery and wound healing. In cosmetics, it is used as a moisturizer and skin conditioner to improve skin texture and elasticity and reduce wrinkles. It can also be found in topical skincare products such as serums, creams, and masks. Additionally, it is used in some injectable dermal fillers to enhance facial features and restore volume loss.
What Can We Supply?
| Grade | Specification | Functions | Applications | Notes |
| HA-EP1.8 | 1.6~2.2 m ³ /kg; < 0.05 IU/mg; 0.5~0.8 million Dalton |
1. Viscoelasticity, protecting corneal endothelium
2. Lubricating, viscoelasticity, Repairing damaged cartilage, inhibiting inflammation, pain relief, etc 3. Good biocompatibility and bio-degradability of HA and its derivatives |
1. Ophthalmic Viscosurgical Devices(OVD)
2. Intra-articular injections 3. Anti-adhesive products, dermal filler, scaffold materials in tissue engineering, etc |
|
| HA-EP-N2.5 | 2.2~3.0 m ³ /kg; < 0.04 IU/mg; 0.5~0.8 million Dalton | |||
| HA-EP-N1.8 | 1.6~2.2 m ³ /kg; < 0.04 IU/mg; 0.5~0.8 million Dalton | |||
| HA-EP-N0.8 | 1.0~1.4m ³ /kg; < 0.04 U/mg; 0.5~0.8 million Dalton |
Eye Drop Grade(Medical Grade)Sodium Hyaluronate
| Grade | Specification | Functions | Applications | Notes |
| HA-EP3.0 | 2.7~3.6 m ³ /kg; < 0.5 IU/mg; 0.5~0.8 million Dalton |
1. Lubricating, moisturizing, improving the efficacy of drugs, relieving dry eye syndrome, and promoting healing of corneal and conjunctival injury
2. Wound Healing 3. Drug or cell carrier/matrix 4. Repairing damaged mucous membranes or cartilage etc |
1. Eye drops, eye lotions, contact lens solutions, medical lubricants, etc
2. Topical preparations ( formulations of gel, film, etc.) 3. Eye drops, cell culture, etc 4. Oral pharmaceutical preparations |
Cosmetic Grade Sodium Hyaluronate
| Specification | Functions | Applications | Notes |
| >1.5million Dalton |
1. A dense biological moisturizing film is formed on the skin surface, which is long-lasting moisturizing and anti-PM2.5
2. Good moisturizing and lubricating properties, slow-release, stable emulsification 3. Repair damaged and early-aged skin; water and soften the stratum corneum, lasting moisturizing, soft skin; Increase skin elasticity and delay skin aging; Promote the proliferation and differentiation of epidermal cells, scavenge oxygen free radicals 4. Transdermal absorption, deep moisturizing. Anti-aging, repair after sun |
1. Skin care products: creams, lotions, lotions, essences, gels, masks, etc
2. Cleaning products: facial cleanser, shower gel, etc 3. Hair products: shampoo, conditioner, hair restorer, hair spray, etc |
|
| 0.8-1.5million Dalton | |||
| <0.1million Dalton | |||
|
<0.01million Dalton |
Food Grade Sodium Hyaluronate
| Specification | Functions | Applications | Notes |
| >1.5million Dalton |
1. Regulate osmotic pressure, maintain tissue morphology, nourish cranial nerves
2.Protect gastric mucosa, lubricate lumen 3. Supplement HA in the body, maintain normal body function, and improve immunity 4. Promote cartilage repair, inhibit inflammation, and relieve soreness 5. Replenish eyeball moisture, and relieve dry, astringent, and itchy eyes 6. Replenish skin moisture, enhance skin elasticity, and reduce wrinkles |
1. Food additive
2. Dietary supplements |
|
| 0.8-1.5million Dalton | |||
| <0.1million Dalton | |||
|
<0.01million Dalton |
The Application of Sodium Hyaluronate
Cosmetics:
Sodium hyaluronate is widely used in cosmetics as a moisturizing and anti-aging agent. It is added to various skincare products, such as creams, serums, and masks, to help improve skin hydration and reduce the appearance of fine lines and wrinkles. Sodium hyaluronate is also used in hair care products to enhance hydration and elasticity.
Dermal Fillers:
Sodium hyaluronate is used in injectable dermal fillers to help restore volume to areas of the face that have lost fat or collagen. Dermal fillers containing sodium hyaluronate are injected into the skin, where they add volume and smooth out wrinkles and fine lines. The effects of these fillers typically last several months to a year, depending on the product and the individual.
Ophthalmology:
Sodium hyaluronate is used in ophthalmology as a viscoelastic agent during eye surgery. It helps to maintain the shape of the eye during surgery and also helps to protect the cornea from damage. Sodium hyaluronate is also used in some contact lens solutions to improve lens comfort and hydration.
Wound Healing:
Sodium hyaluronate is used in wound healing as a dressing or spray. It helps to keep the wound moist and prevent the formation of scabs, which can impede recovery. Sodium hyaluronate is also believed to have anti-inflammatory properties, which can help to reduce pain and swelling associated with wounds.
Joint Injections:
Sodium hyaluronate is used in injections to treat joint disorders like osteoarthritis. Injections of sodium hyaluronate into the joint can help to lubricate the joint, reduce inflammation, and improve mobility.
Drug Delivery:
Sodium hyaluronate is being investigated as a drug delivery vehicle for various drugs, including chemotherapy. The large size of the sodium hyaluronate molecule makes it ideal for encapsulating drugs and delivering them to specific tissues or cells. Sodium hyaluronate can also help prolong drug release, making them more effective.
The Function of Sodium Hyaluronate
Hydration: One of the main functions of sodium hyaluronate is to hydrate the skin or other tissues. Sodium hyaluronate can hold up to 1,000 times its weight in water, making it an excellent moisturizer. When applied to the skin or injected into tissues, sodium hyaluronate helps to restore moisture and improve skin or tissue hydration.
Lubrication: Sodium hyaluronate also has lubricating properties, particularly in joints. It helps to reduce friction between joint surfaces and improve joint mobility. This makes it beneficial in joint injections for conditions such as osteoarthritis.
Anti-inflammatory: Sodium hyaluronate has been found to have anti-inflammatory properties, which can help to reduce pain and swelling. It is thought to inhibit the production of pro-inflammatory cytokines and enzymes, reducing inflammation.
Tissue Regeneration: Sodium hyaluronate has been found to stimulate tissue regeneration in various tissues, including skin and bone. It can help to promote the growth of new cells and tissues, leading to faster healing and tissue repair.
Anti-aging: Sodium hyaluronate is a popular ingredient in anti-aging skincare products due to its ability to improve hydration and reduce the appearance of fine lines and wrinkles. It helps plump the skin and improve skin elasticity, leading to a more youthful appearance.
Molecular Structure of Sodium Hyaluronate
Specification Standards for Sodium Hyaluronate
1. High Molecular Weight (HMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white powder or granule | Complied |
| PH(1% water solution) | 5.0~8.5 | 7.1 |
| Transmittance | T 550nm ≥99.0% | 99.8% |
| Absorbance | A 280nm ≤0.25 | 0.15 |
| Loss on drying | ≤10.0% | 6.4% |
| Glucuronic acid | ≥45.0% | 47.16% |
| Sodium hyaluronate | ≥93.0% | 97.50% |
| Molecular weight, Dalton | measured value | 2.0*10 6 Dalton |
| Intrinsic viscosity | measured value | 29.6dL/g |
| Kinematic viscosity | measured value | 64.6mm 2 /s |
| Protein | ≤0.1% | 0.05% |
| Heavy Metals | ≤20mg/kg | <10mg/kg |
| Bacteria counts | ≤100cfu/g | Complied |
| Mold & Yeast | ≤50cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Pseudomonas aeruginosa | Negative/g | Negative |
2. Medium Molecular Weight (MMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white powder or granule | Complied |
| PH | 6.0~8.0 | 6.7 |
| Transmittance | T 600nm ≥99.0% | 99.8% |
| Loss on drying | ≤10.0% | 6.4% |
| Glucuronic acid | ≥44.5% | 47.2% |
| Sodium hyaluronate | ≥92.0% | 97.6% |
| Molecular weight, Dalton | measured value | 1.00*10 6 Dalton |
| Intrinsic viscosity | measured value | 17.1dL/g |
| The bulk density | measured value | 0.32g/cm 3 |
| The tap density | measured value | 0.49g/cm 3 |
| Protein | <0.1% | 0.05% |
| Ash | ≤13.0% | <13.0% |
| Heavy Metal(as Pb) | ≤10mg/kg | <10mg/kg |
| Arsenic | ≤2mg/kg | <2mg/kg |
| Bacteria counts | ≤100cfu/g | Complied |
| Mold & Yeast | ≤50cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Escherichia coli | Negative/g | Negative |
| Salmonella | Negative/25g | Negative |
3. Low Molecular Weight (LMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white powder or granule | Complied |
| PH(1% water solution) | 5.0~8.5 | 7.0 |
| Transmittance | T 550nm ≥99.0% | 99.8% |
| Absorbance | A 280nm ≤0.25 | 0.17 |
| Loss on drying | ≤10.0% | 7.4% |
| Glucuronic acid | ≥45.0% | 47.21% |
| Sodium hyaluronate | ≥93.0% | 97.6% |
| Molecular weight, Dalton | measured value | 2.0*10 5 Dalton |
| Intrinsic viscosity | measured value | 4.91dL/g |
| Kinematic viscosity | measured value | 4.61mm 2 /s |
| Protein | ≤0.1% | 0.05% |
| Heavy Metals | ≤20mg/kg | <10mg/kg |
| Bacteria counts | ≤100cfu/g | Complied |
| Mold & Yeast | ≤50cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Pseudomonas aeruginosa | Negative/g | Negative |
4. Very Low Molecular Weight (VLMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white, very hygroscopic powder or fibrous aggregate | Complied |
| PH(1% water solution) | 5.0~8.5 | 7.0 |
| Solubility | Sparingly soluble or soluble in water, practically insoluble in acetone and in anhydrous ethanol | Complied |
| Identification | A. Infrared absorption spectrophotometry | Complied |
| B. It gives reaction (a) of sodium | Complied | |
| Loss on drying | ≤10.0% | 5.7% |
| Sodium hyaluronate | ≥95.0% | 97.0% |
| Appearance of solution | A 600nm ≤0.01 | Complied |
| Nucleic acids | A 260nm ≤0.5 | Complied |
| Molecular weight, Dalton | measured value | 10,000 Dalton |
| Intrinsic viscosity | measured value | 0.19dL/g |
| Protein | ≤0.1% | 0.06% |
| Chlorides | ≤0.5% | Complied |
| Iron | ≤80ppm | < 80ppm |
| TAMC | ≤100cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Pseudomonas aeruginosa | Negative/g | Negative |
Cosmetic grade: Sodium hyaluronate is a popular ingredient in cosmetics and personal care products due to its moisturizing and anti-aging properties. As mentioned in my previous answer, cosmetic-grade sodium hyaluronate should meet certain specifications regarding its molecular weight, purity, and degree of cross-linking.
1. High Molecular Weight (HMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white powder or granule | Complied |
| PH(1% water solution) | 5.0~8.5 | 6.6 |
| Transmittance | T 550nm ≥99.0% | 99.8% |
| Absorbance | A 280nm ≤0.25 | 0.15 |
| Loss on drying | ≤10.0% | 5.9% |
| Glucuronic acid | ≥45.0% | 47.6% |
| Sodium hyaluronate | ≥93.0% | 98.4% |
| Molecular weight, Dalton | measured value | 2.0*10 6 Dalton |
| Intrinsic viscosity | measured value | 29.6dL/g |
| Kinematic viscosity | measured value | 64.6mm 2 /s |
| Protein | ≤0.1% | 0.05% |
| Heavy Metals | ≤20mg/kg | <10mg/kg |
| Bacteria counts | ≤100cfu/g | Complied |
| Mold & Yeast | ≤50cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Pseudomonas aeruginosa | Negative/g | Negative |
2. Medium Molecular Weight (MMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white powder or granule | Complied |
| PH(1% water solution) | 5.0~8.5 | 6.5 |
| Transmittance | T 550nm ≥99.0% | 99.9% |
| Absorbance | A 280nm ≤0.25 | 0.11 |
| Loss on drying | ≤10.0% | 7.0% |
| Glucuronic acid | ≥45.0% | 47.4% |
| Sodium hyaluronate | ≥93.0% | 98.1% |
| Molecular weight, Dalton | measured value | 1.00*10 6 Dalton |
| Intrinsic viscosity | measured value | 17.2dL/g |
| Kinematic viscosity | measured value | 34.0mm 2 /s |
| Protein | ≤0.1% | 0.04% |
| Heavy Metals | ≤20mg/kg | <10mg/kg |
| Bacteria counts | ≤100cfu/g | Complied |
| Mold & Yeast | ≤50cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Pseudomonas aeruginosa | Negative/g | Negative |
3. Low Molecular Weight (LMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white powder or granule | Complied |
| PH(1% water solution) | 5.0~8.5 | 6.5 |
| Transmittance | T 550nm ≥99.0% | 99.9% |
| Absorbance | A 280nm ≤0.25 | 0.07 |
| Loss on drying | ≤10.0% | 6.9% |
| Glucuronic acid | ≥45.0% | 46.4% |
| Sodium hyaluronate | ≥93.0% | 96.1% |
| Molecular weight, Dalton | measured value | 1.0*10 5 Dalton |
| Intrinsic viscosity | measured value | 2.86dL/g |
| Kinematic viscosity | measured value | 2.32mm 2 /s |
| Protein | ≤0.1% | 0.05% |
| Heavy Metals | ≤20mg/kg | <20mg/kg |
| Bacteria counts | ≤100cfu/g | Complied |
| Mold & Yeast | ≤50cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Pseudomonas aeruginosa | Negative/g | Negative |
4. Very Low Molecular Weight (VLMW) Sodium Hyaluronate
| Test Items | Specification | Test Result |
| Appearance | White or almost white powder or granule | Complied |
| PH(1% water solution) | 5.0~8.5 | 6.6 |
| Transmittance | T 550nm ≥99.0% | 99.9% |
| Absorbance | A 280nm ≤0.25 | 0.05 |
| Loss on drying | ≤10.0% | 6.5% |
| Glucuronic acid | ≥45.0% | 47.0% |
| Sodium hyaluronate | ≥93.0% | 97.2% |
| Molecular weight, Dalton | measured value | 1.0*10 4 Dalton |
| Intrinsic viscosity | measured value | 0.47dL/g |
| Kinematic viscosity | measured value | 1.05mm 2 /s |
| Protein | ≤0.1% | 0.03% |
| Heavy Metals | ≤20mg/kg | <10mg/kg |
| Bacteria counts | ≤100cfu/g | Complied |
| Mold & Yeast | ≤50cfu/g | Complied |
| Staphylococcus aureus | Negative/g | Negative |
| Pseudomonas aeruginosa | Negative/g | Negative |
Medical grade: Sodium hyaluronate can also be used in various medical applications, such as joint injections for the treatment of osteoarthritis, as well as in wound healing and tissue regeneration. Medical-grade sodium hyaluronate must meet specific purity, molecular weight, and viscosity requirements as set by regulatory agencies such as the FDA in the United States and the European Medicines Agency (EMA) in Europe.
1. Eyedrop Grade Sodium Hyaluronate HA-E3.0
| Product | Sodium hyaluronate | Grade | HA-E3.0 | ||
| Batch No. | 22062201 | Batch size | 40.76kg | ||
| Intrinsic viscosity | 2.7~3.6 m^3/kg | Production date | 2023.06.19 | ||
| Standard | Ph.Eur.10.0 | Expiry date | 2025.06.19 | ||
| Items | Acceptance criteria | Results | |||
| Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
|
Consistent with the reference substance spectrum of sodium hyaluronate Positive |
Complies
Positive |
|||
| Appearance of solution |
Clear
A600nm ≤ 0.01 |
Clear
0.00 |
|||
| pH | 5.0~8.5 | 6.6 | |||
| Intrinsic viscosity | 2.7~3.6 m^3/kg | 3.27 m^3/kg | |||
| Nucleic acids | A260nm ≤ 0.5 | 0.01 | |||
| Protein | ≤ 0.1% | < 0.0004% | |||
| Chlorides | ≤ 0.5% | < 0.5% | |||
| Iron | ≤ 30 ppm | < 2 ppm | |||
| Loss on drying | ≤ 20.0% | 13.1% | |||
|
Microbial contamination
(TAMC) |
≤ 100 cfu/g | < 20 cfu/g | |||
| Bacterial Endotoxins | < 0.5 IU/mg | < 0.5 IU/mg | |||
| Residual solvents (Ethanol) | ≤ 5000 ppm | < 24 ppm | |||
| Formaldehyde | ≤ 100 ppm | 10 ppm | |||
| Assay | 95.0%~105.0%(dried substance) | 100.1% | |||
2. Injection Grade Sodium Hyaluronate HA-EP1.8
| Product | Sodium hyaluronate | Grade | HA-EP1.8 | ||
| Batch No. | 22051311 | Batch size | 6.370kg | ||
| Intrinsic viscosity | 1.6~2.2 m^3/kg | Production date | 2023.05.14 | ||
| Standard | Ph.Eur.10.0 | Expiry date | 2025.05.14 | ||
| Items | Acceptance criteria | Results | |||
| Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
|
Consistent with the reference substance spectrum of sodium hyaluronate Positive |
Complies
Positive |
|||
| Appearance of solution |
Clear
A600nm ≤ 0.01 |
Clear
0.00 |
|||
| pH | 5.0~8.5 | 6.2 | |||
| Intrinsic viscosity | 1.6~2.2 m^3/kg | 1.85 m^3/kg | |||
| Nucleic acids | A260nm ≤ 0.5 | 0.01 | |||
| Protein | ≤ 0.1% | < 0.0004% | |||
| Chlorides | ≤ 0.5% | < 0.5% | |||
| Iron | ≤ 30 ppm | 2 ppm | |||
| Loss on drying | ≤ 15.0% | 9.2% | |||
|
Microbial contamination
(TAMC) |
≤ 100 cfu/g | < 20 cfu/g | |||
| Bacterial Endotoxins | < 0.05 IU/mg | < 0.05 IU/mg | |||
| Residual solvents (Ethanol) | ≤ 5000 ppm | < | |||
| Residual solvents (Methanol) | ≤ 300 ppm | < 32 ppm | |||
| Formaldehyde | ≤ 50 ppm | < 5.2 ppm | |||
| Assay | 95.0%~105.0%(dried substance) | 100.2% | |||
3. Injection Grade Sodium Hyaluronate HA-EP-N 2.5
| Product | Sodium hyaluronate | Grade | HA-EP-N 2.5 | ||
| Batch No. | 22023501 | Batch size | 40.84kg | ||
| Intrinsic viscosity | 2.2~3.0 m^3/kg | Production date | 2023.02.22 | ||
| Standard | Ph.Eur.10.0 | Expiry date | 2025.02.22 | ||
| Items | Acceptance criteria | Results | |||
| Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
|
Consistent with the reference substance spectrum of sodium hyaluronate Positive |
Complies
Positive |
|||
| Appearance of solution |
Clear
A600nm ≤ 0.01 |
Clear
0.00 |
|||
| pH | 5.5~7.0 | 6.4 | |||
| Intrinsic viscosity | 2.2~3.0 m^3/kg | 2.45 m^3/kg | |||
| Nucleic acids | A260nm ≤ 0.1 | 0.01 | |||
| Protein | ≤ 0.1% | < 0.0004% | |||
| Chlorides | ≤ 0.1% | < 0.1% | |||
| Iron | ≤ 20 ppm | 4 ppm | |||
| Loss on drying | ≤ 10.0% | 7.2% | |||
|
Microbial contamination
TAMC TYMC |
≤ 100 cfu/g ≤ 100 cfu/g |
< 20 cfu/g < 20 cfu/g |
|||
| Bacterial Endotoxins | < 0.04 IU/mg | < 0.04 IU/mg | |||
| Residual solvents (Ethanol) | ≤ 5000 ppm | < 24 ppm | |||
| Assay | 95.0%~105.0%(dried substance) | 99.6% | |||
4. Injection Grade Sodium Hyaluronate HA-EP-N 1.8
| Product | Sodium hyaluronate | Grade | HA-EP-N 1.8 | ||
| Batch No. | 22023402 | Batch size | 41.63kg | ||
| Intrinsic viscosity | 1.6~2.2 m^3/kg | Production date | 2023.02.01 | ||
| Standard | Ph.Eur.10.0 | Expiry date | 2025.02.01 | ||
| Items | Acceptance criteria | Results | |||
| Characters | White or almost white powder or fibrous aggregate | White powder | |||
Identification
|
Consistent with the reference substance spectrum of sodium hyaluronate Positive |
Complies
Positive |
|||
| Appearance of solution |
Clear
A600nm ≤ 0.01 |
Clear
0.00 |
|||
| pH | 5.5~7.0 | 6.5 | |||
| Intrinsic viscosity | 1.6~2.2 m^3/kg | 1.84 m^3/kg | |||
| Nucleic acids | A260nm ≤ 0.1 | 0.01 | |||
| Protein | ≤ 0.1% | < 0.0004% | |||
| Chlorides | ≤ 0.1% | < 0.1% | |||
| Iron | ≤ 20 ppm | 7 ppm | |||
| Loss on drying | ≤ 10.0% | 7.9% | |||
|
Microbial contamination
TAMC TYMC |
≤ 100 cfu/g ≤ 100 cfu/g |
< 20 cfu/g < 20 cfu/g |
|||
| Bacterial Endotoxins | < 0.04 IU/mg | < 0.04 IU/mg | |||
| Residual solvents (Ethanol) | ≤ 5000 ppm | < 26 ppm | |||
| Assay | 95.0%~105.0%(dried substance) | 100.2% | |||
It's important to note that these grades of sodium hyaluronate are not interchangeable, and a product intended for one use may not be suitable for another use. For example, food-grade sodium hyaluronate should not be used in medical or cosmetic applications, as it may not meet the necessary purity or quality standards. Similarly, medical-grade sodium hyaluronate should not be used in food products, as it may be unsafe for ingestion.
The Production Process of Sodium Hyaluronate
Preparation of Fermentation Medium: The fermentation medium is prepared by dissolving glucose and yeast powder in water and adding magnesium sulfate and sodium hydroxide. The solution is sterilized by autoclaving to ensure no bacteria or other contaminants are present.
Fermentation: The sterilized fermentation medium is then inoculated with a hyaluronic acid-producing bacterial strain, and the fermentation process can proceed for several days. During this time, the bacteria convert the glucose in the medium into hyaluronic acid monomers through metabolic conversion. The bacteria grow and multiply, producing more and more hyaluronic acid.
Precipitation and Centrifuge Separation: Once the fermentation process is complete, the hyaluronic acid is harvested from the broth. This is done by adding a salt solution to the broth, which causes the hyaluronic acid to precipitate out of the solution. The precipitated hyaluronic acid is then separated from the broth by centrifugation.
Crude Polymer Sodium Hyaluronate: The resulting material is a crude polymer of sodium hyaluronate, which still contains impurities and other substances. This material is dissolved in water and filtered to remove any remaining particulates or contaminants.
Twice-Precipitation: The filtered solution of sodium hyaluronate is then subjected to a process known as twice-precipitation. This involves adding a specific type and amount of salt to the solution, which causes the hyaluronic acid to precipitate out of the key again. The precipitated hyaluronic acid is separated from the solution by centrifugation, and this process is repeated to ensure that the final product is as pure as possible.
Drying and Packing: The purified hyaluronic acid is then dried using a spray dryer, which removes any remaining moisture from the product. The dried powder is then packed into containers for storage and shipment.
Baoding Faithful Industry Co., Ltd. was established in 2005 and is located in the National High Tech Industrial Science and Technology Park of Baoding City, Hebei Province. It specializes in researching, producing, and selling raw materials for health products. Its main products include sodium hyaluronate, collagen, trypsin, gastric enzymes, and plant extracts. Our products are exported to over 20 countries, including the Americas, Europe, and Asia. We have extensive markets and research centers in the United States, Germany, Japan, and other places and a vast database of cutting-edge skin biology that accurately captures global trends. The laboratory has senior engineers and high-end experimental equipment, pursuing ultimate scientificity and safety and meeting consumers' high requirements for quality of life. We have established a comprehensive service system from quality control and sales to after-sales service and have passed the ISO9001 quality management system. We will provide new and old cosmetics customers with higher quality products, higher quality, more complete, and more thoughtful services.
FAQ
1. Although 80,000 molecular weight Hyaluronic acid is excellent absorption and penetration of the skin but is not thick enough, 1.2 million molecular weight Hyaluronic acid, although wide but not good skin penetration, want thick Hyaluronic acid, the most cost-effective way is what?
A: Suggest high molecular weight and low molecular weight mix achieve both dense and can be very good skin penetration; absorption effect is good.
2. The difference between different molecular weights
A: High molecular weight HA is more stable and suitable for some cream-type cosmetics. Hyaluronic acid of moderate molecular weight is more accessible to absorb than that of high molecular weight, so it is suitable for use in thin cream. Low molecular weight Hyaluronic acid is easily absorbed by the skin and is suitable to be added to hydrating masks and hydrating products.
3. What's the difference between Sodium hyaluronate and hyaluronic acid.
A: Hyaluronic acid exists in human and animal organs and tissues. Human beings use modern scientific production technology -- biological fermentation method to produce Hyaluronic acid in the form of sodium salt, which is used by human beings.
4. What is our minimum order quantity?
A: The minimum order quantity for food grade and cosmetic grade is 100g, and the minimum order quantity for the pharmaceutical grade is 1g.
5. Do we have any discounts on our products?
A: Yes, for larger quantities, we always provide support at more favorable prices.
6. How to start placing orders or making payments?
A: You can send us your purchase order (if your company has one) or send a simple confirmation via email or trade manager. We will send you a formal invoice with our bank details for confirmation, and you can make the payment accordingly.
7. How to ensure the quality of the product?
A: Our company has multiple high-end imported devices, including high-performance liquid chromatography, gas chromatography, and atomic absorption spectroscopy. We have established a comprehensive quality management system following GMP requirements and strictly controlling the quality. We also accept testing by third-party testing agencies such as SGS and Eurofins. In addition, you can obtain samples and send us your product specifications and requirements, and we will manufacture the product according to your needs.
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Feed Grade Private Label Organic Vegan Pea Protein Isolate Powder
Wholesale Food Grade 25kg/Bag/Drum Taurine Feed Grade Raw Material Taurine
N-Acetylneuraminic Acid/Sialic Acid for Beauty
Origin Facotry Food Grade Serrapeptase Powder CAS 95077-02-4 Enzyme Serrapeptase
Hot Selling Dl-Methionine for Pourty
Tongkat Ali Extract 1%~15% Eurycomanone Powder Eurycomanone CAS 84633-29-4
Factory Supply Taurine CAS 107-35-7
Calcium Ascorbate Bulk Powder E302 with Purity of 99%
Health Food Calcium Citrate USP32 CAS 813-94-5 White Powder Used as a Preservative/ Acidity Regulator
Food Grade Calcium D-Glucarate Powder
Industrial/Food/Feed/ Pharma Grade Food Additives Glycine with Low Price