Ethylenebis(oxyethylenenitrilo)tetraacetic acid Chemical Properties |
Melting point | 241 °C (dec.)(lit.) |
Boiling point | 507.99°C (rough estimate) |
density | 1.2838 (rough estimate) |
refractive index | 1.4590 (estimate) |
storage temp. | room temp |
solubility | 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless |
pka | 1.47±0.10(Predicted) |
form | Crystalline Powder |
color | White |
Water Solubility | slightly soluble |
Merck | 14,3529 |
BRN | 1717370 |
CAS DataBase Reference | 67-42-5(CAS DataBase Reference) |
EPA Substance Registry System | Ethylenebis(oxyethylenenitrilo)tetraacetic acid (67-42-5) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 24/25-36-26 |
WGK Germany | 2 |
RTECS | AH3760000 |
TSCA | Yes |
HS Code | 29225000 |
Toxicity | LD50 orally in Rabbit: 3587 mg/kg |
MSDS Information |
Ethylenebis(oxyethylenenitrilo)tetraacetic acid Usage And Synthesis |
Description | Ethylenebis(oxyethylenenitrilo)tetraacetic acid is also named as Egtazic acid. It works as a chelating agent for the determination of calcium in the presence of magnesium. |
Chemical Properties | White to slightly off-white powder |
Uses | Pharmaceutic aid. EGTA. |
Definition | ChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively. |
Biological Activity | Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells. |
Safety Profile | Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also GLYCOL ETHERS. |
Purification Methods | Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.] |