Brief Introduction
Name	Meldrum's Acid
Synonyms	2,2-Dimethyl-1,3-Dioxane-4,6-Dione
	Isopropylidene Malonate
	Malonic Acid Cyclic Isopropylidene Ester
	Cyclic Isopropylidene Malonate
CAS	2033-24-1
EINECS	217-992-8
Molecular Formula	C6H8O4
Molecular weight	144.13
Pureness	≥99%
Production Capacity	200 tons/month

Properties
Density	1.1311 (rough estimate)
Melting Point	92-96°C(lit.)
Boling Point	182.71°C (rough estimate)
Flash Point	150.1°C
Water Solubility	2.5 g/100 mL (20 ºC)
Vapor Presure	0.044-133Pa at 25 ºC
Appearance	White crystalline powder
Merck	145817
BRN	117310
pKa	5.1(at 25ºC)
Storage Condition	2-8°C
Refractive Index	1.4434 (estimate)
MDL	MFCD00006638
InChI	InChI=1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3
InChIKey	GXHFUVWIGNLZSC-UHFFFAOYSA-N

Product Description
Due to its unique structure and the vast array of substituents that can be attached to its core, Meldrum's acid is a molecule with exceptional chemical properties. In water, it has a remarkably low pKa value of about 4.9. Its C5 position is readily involved in electrophilic substitution reactions whereas the C4 and C6 positions are easily attacked by nucleophiles. At elevated temperatures Meldrum's acid undergoes distinctive decomposition pathways, which can be used in cycloaddition and acylation reactions.  

Solubility
Meldrum's acid or 2,2-dimethyl-1,3-dioxane-4,6-dione is an organic compound with formula . Its molecule has a heterocyclic core with four carbon and two oxygen atoms; the formula can also be written as [−O− (C (CH3)2)−O− (C=O)− (CH2)− (C=O)−]  . It is a crystalline colorless solid, sparingly soluble in water. It decomposes on heating with release of carbon dioxide and acetone.

Stability

1. It will not decompose if used and stored according to specifications. No known hazard reactions. Avoid oxides, moisture/moisture.
2. It ' s very stable and can be stored for a long time at room temperature.

Application

Application

1. It's used as a pharmaceutical intermediate. The ring (sub) isopropyl malonate can be used as an intermediate in pharmaceutical synthesis, and it can be used to prepare the compound 3-oxo-4-phenylvalerate Ethyl, further preparation of 3, 4-disubstituted-6-phenylethylpyridinone HIV-1 reverse transcriptase inhibitors.

2. It's used in organic synthesis. T he protective reagent   is obtained by aldol condensation and reduction with triethylamine formaldehyde. the benzyl substituted michele acid is hydrolyzed, lost CO2 and chlorosulfonic acid for Friedel-Crafts cyclization to produce 2, 3-dihydro-2-indanone. Accelerate the Noven Gall concentration reaction between aldehyde and Michaelis acid in ionic liquid (Knoevenagel condensations).

 

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