Wholesale Chemical Raw Material Powder Gabapentin, , 99%Purity CAS 60142 -96-3

Model NO.
60142-96-3
Colour
White
Melting Point
162°c
Flash Point
144.0±20.4 °c
Boiling Point
314.4±15.0 °c at 760 Mmhg
Molecular Weight
171.237
Transport Package
According to Customer Demand
Specification
1kg
Trademark
congchang
Origin
Hebei
HS Code
2922499990
Production Capacity
100000
Reference Price
$ 45.00 - 117.00
Contact Us

Product Description


 
Product Description
Density 1.1±0.1 g/cm3
Boiling Point 314.4±15.0 °C at 760 mmHg
Melting Point 162°C
Molecular Formula C 9 H 17 NO 2
Molecular Weight 171.237
Flash Point 144.0±20.4 °C
Exact Mass 171.125931
PSA 63.32000
LogP 1.19
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.489
Storage condition Desiccate at +4°C
Water Solubility H2O: 10 mg/mL
   
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain.IC50 Value: 140 nM (α2δ subunit of calcium channel) Target: Calcium Channelin vitro: Gabapentin, baclofen and CGP 44532 all reduced the electrically stimulated release of [3H]glutamic acid (IC50=20 microM, 0.8 microM and 2 microM, respectively). Gabapentin was without effect on the release of [3H]GABA, whilst baclofen (IC50=8 microM) and CGP 44532 (IC50=1 microM) inhibited [3H]GABA release . A large inhibition of calcium currents by gabapentin was observed in pyramidal neocortical cells (up to 34%). Significantly, the gabapentin-mediated inhibition of calcium currents saturated at particularly low concentrations (around 10 microM), at least in neocortical neurons (IC50 about 4 microM) .in vivo: Gabapentin produced an anti-allodynic effect over the 7-day period, reducing the expression of pro-inflammatory cytokines but increasing the expression of IL-10 (TNF-α, 316.0 ± 69.7 pg/mL vs 88.8 ± 24.4 pg/mL; IL-1β, 1,212.9 ± 104.5 vs 577.4 ± 97.1 pg/mL; IL-6, 254.0 ± 64.8 pg/mL vs 125.5 ± 44.1 pg/mL; IL-10, 532.1 ± 78.7 pg/mL vs 918.9 ± 63.1 pg/mL). The suppressive effect of gabapentin on pro-inflammatory cytokine expression was partially blocked by the anti-IL-10 antibody .Toxicity: No new safety signals or adverse event trends relating to GEn exposure were identified .Clinical trial: N/A
Wholesale Chemical Raw Material Powder Gabapentin, , 99%Purity CAS 60142-96-3
Wholesale Chemical Raw Material Powder Gabapentin, , 99%Purity CAS 60142-96-3
 
Packaging & Shipping

Wholesale Chemical Raw Material Powder Gabapentin, , 99%Purity CAS 60142-96-3 Wholesale Chemical Raw Material Powder Gabapentin, , 99%Purity CAS 60142-96-3

Company Profile

 

Wholesale Chemical Raw Material Powder Gabapentin, , 99%Purity CAS 60142-96-3
Our Advantages

Wholesale Chemical Raw Material Powder Gabapentin, , 99%Purity CAS 60142-96-3

FAQ

 

 

 

Organic Intermediate