Buy Honokiol CAS 35354-74-6 with good price

Pharmacological action
1. The role of pathogenic microorganisms
It can inhibit gram-positive bacteria such as Staphylococcus, hemolytic streptococcus, pneumococcus, pertussis bacillus and Gram-negative bacteria such as anthrax, dysentery bacillus, typhoid bacillus, paratyphoid bacillus, Vibrio cholerae, Escherichia coli, Proteus bacillus, subtilis bacillus and diphtheria bacillus, among which staphylococcus has the strongest inhibitory effect. When the concentration was 15%, it could inhibit the skin fungi such as microsporon, trichophyton concentric, trichophyton rubrum and Trichophyton escens in experimental animals. Houpu decoction can ameliorate substantive pathological lesion of experimental viral hepatitis in mice. Magnolol has significant antibacterial activity against Gram-positive bacteria and acid-resistant bacteria. The antibacterial activity of magnolol was higher than that of the typical antibacterial alkaloid Berberine (MIC: 50μg/ml). The lowest inhibitory concentration was 6.3μg/ml. The saturated aqueous solution of magnolia officinalis and essential oil of magnolia officinalis has certain antibacterial effect on Staphylococcus aureus, Bacillus Sarcina and Bacillus subtilis.
2. Effect on cardiovascular system
Honokiol and honokiol inhibit thromboxane B2 formation in various situations, and intracellular Ca2+ elevation caused by arachidonic acid or collagen is also inhibited by both. Honokiol can inhibit the activity of cyclic nucleotide phosphodiesterase stimulated by CaM, and honokiol can bind to CaM in the presence of Ca2+, thus antagonizing its activation of phosphodiesterase. In addition, honokiol can stimulate the basic activity of CAM-dependent phosphodiesterase. 3. Anti-tumor effect magnolol and its hydroxymethyl derivatives have obvious inhibitory effect on the second stage skin tumor in mice. Three extracts of magnolia officinae lignans, magnolol, magnolol and monoterpene magnolol are antagonists of 12-O-tetradecanoyl fobolol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBv-EA) activation.

Toxic and side reaction
Magnolia officinalis is less toxic. The LD50 of Magnolia decoction was 6.12±0.038g/kg, while the LD50 of magnolia curarine was 45.55mChemicalbookg/kg. The MLD of Houpu decoction for cats was 4.25±1.25g/kg. Under normal muscle relaxation dose, electrocardiogram of experimental animals has no effect, and large dose can cause respiratory depression and death.

Application overview
Magnolia officinalis is a traditional Chinese medicine used in Houpu Sanwu Decoction, Banxia Houpu Decoction, Dachengqi decoction, Xiangsha stomach-nourishing capsule, Huoxiang Zhengqi water (pill) and other prescriptions. In recent years, through the in-depth study of the active ingredients, pharmacodynamics and clinical pharmacy of Magnolia officinalis, domestic and foreign scholars have appeared on the market, such as anti-caries toothpaste and antibacterial "gum" prepared by Magnolia Officinalis extract.

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