Puya Supply Gliclazide CAS 21187-98-4 Treatment Of Diabetes

Product Name:    Gliclazide
Synonyms:    Gliclazide, BP;)-4-methyl-;1-(3-azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea;1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)-ure;1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)urea;benzenesulfonamide,n-(((hexahydrocyclopenta(c)pyrrol-2(1h)-yl)amino)carbonyl;n-(4-methylbenzenesulfonyl)-n'-(3-azabicyclo(3.3.0)oct-3-yl)urea;Tetrabenzyl Voglibose HCl
CAS:    21187-98-4
MF:    C15H21N3O3S
MW:    323.41
EINECS:    244-260-5
Product Categories:    Anti diabetic;Pharmaceutical intermediates;Potassium channel;Aromatics;Sulfur & Seleniu m Compounds;Other APIs;Pharmaceutical;Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Pharmaceuticals;API's
Mol File:    21187-98-4.mol



Gliclazide is an oral antihyperglycemic agent used for the treatment of diabetes mellitus type II. It belongs to the sulfonylurea class of insuli n secretagogues, which stimulates β cells of the pancreas to release insuli n. Gliclazide binds to the β cell sulfonyl urea receptor (SUR1), further blocking the ATP sensitive potassium channels. Therefore, the potassium efflux substantially decreases, causing depolarization of the β cells. Then the voltage-dependent calcium channels in the β cell are open, resulting in calmodulin activation, which in turn leads to exocytosis of insuli n containing secretorty granules. Recent studies have also shown that gliclazide can effectiveimprove anti-oxidant status and nitric oxide-mediated vasodilation in Type 2 diabetes and protect pancreatic beta-cells from damage by hydrogen peroxi de.

Gliclazide CAS 21187-98-4  of Chemical Properties
Melting point     163-169 °C (lit.)
density     1.2205 (rough estimate)
refractive index     1.6740 (estimate)
storage temp.     2-8°C
solubility     methylene chlori de: soluble
pka    6.07±0.10(Predicted)
form     powder
color     white
Merck     14,4439
InChIKey    BOVGTQGAOIONJV-UHFFFAOYSA-N
CAS DataBase Reference    21187-98-4(CAS DataBase Reference)
EPA Substance Registry System    Benzenesulfonamide, N-[[(hexahydrocyclopenta[c]pyrrol-2(1H)-yl)amino]carbonyl]-4-methyl (21187-98-4)


Function and Application of  Gliclazide CAS 21187-98-4

Company Profile
Anhui puya biological technology co.,ltd was established in Hefei. Registered capital is 5 million. It is specialized in manufacture plant extract, API and chemicals raw material powder, food additives and oil. which are applied to skin care, healthcare, weight loss products, sex improvement, and pharmaceuticals. We will uphold honesty and pragmatic, innovative and enterprising service purposes, and provide a variety of quality services to our customers at abroad. It aims at supplying good product and comfort service. The strict quality control is to meet the customer's requirement, to get a highly praised and to be high quality supplier. If you have any question, or need samples, please feel free to contact us.

FAQ
Q1. What's the MOQ?
A: Usually 1 kg.  It is based on the different product. Some are 1g and some are 1 ton. Please be free to consult our salesman.
 
Q2. What's the shipping time?
A: If in stock, we will ship it out immediately.  By FedEx will be 3~5 days to you.
 
Q3. If I need less than the MOQ, is it possible?
A: Yes. Please be free to consult our salesman.
 
Q4. Can you supply the free sample?
A: Usually it is possible. but the shipping cost be paid by customers. It based on the different product. Please be free to consult our salesman.
 
Q5. How to store the product?
A: Store in cool and dry place. It must be in well closed containers. The shelf life will be 2 years.
 
Q6: What's your main payment method?
A: T/T, trade assurance, west union, money gram.
 
Q7: Do you have COA, MSDS, CO, Health certificate, form 9 or other certificate?
A: Yes, we have. pls be free to contact us to get updated one.