Product Name:  Hinokitiol
CAS No.:    499-44-5
 
Hinokitiol CAS 499-44-5 also known as chamaecolol, is a monoterpenoid natural compound with skeleton extracted from the trunk of Platycladus orientalis in 1948. Hinokitiol CAS 499-44-5 belongs to the tophenone family. It has good antibacterial, moisturizing and insect repellent effects. It is a high safety plant component. Hinokitiol CAS 499-44-5 can be used as antibacterial and insect repellent. It is the main component of essential oil of Platycladus orientalis, Hinokitiol CAS 499-44-5 has a wide range of biological activities.

Hinokitiol CAS 499-44-5 has strong bactericidal ability. The minimum inhibitory concentration on general bacteria is 10-100ppm. Hinokitiol CAS 499-44-5 smells fragrant and has good effect. Hinokitiol CAS 499-44-5 can kill bacteria and micro bacteria in the air, prevent pests from invading human body and inhibit human pathogenic bacteria. At present, Hinokitiol CAS 499-44-5 has been used in the production of shower gel, cosmetics, medicine and other products. Hinokitiol CAS 499-44-5 has an amazing effect on inhibiting Staphylococcus aureus.

The bacteria often exist in human skin and respiratory tract, causing skin infections such as sepsis, peritonitis, food poisoning, sores, furuncle and abscess. Hinokitiol CAS 499-44-5 is the key enzyme in the formation of melanin. Hinokitiol CAS 499-44-5 can catalyze the conversion of light into eumelanin and brown pigment through multiple ways, resulting in the formation of freckles, chloasma and pregnancy spots.


In vitro experiments showed that Hinokitiol CAS 499-44-5 had a strong inhibitory effect on tyrosinase bisphenol enzyme. With DOPA as substrate, the enzyme activity decreased by 50%, and the concentration of Hinokitiol CAS 499-44-5 was 0.3umol/l. The inhibition is reversible, indicating that Hinokitiol CAS 499-44-5 only inhibits the activity of tyrosinase without causing permanent inactivation of the enzyme. The good regulation mechanism of Hinokitiol CAS 499-44-5 on tyrosinase in melanocytes is closely related to its structure. Tyrosinase is a ketone containing oxidoreductase.

The warp group at position 2 and the ketone structure at position 1 can combine with the copper atom of tyrosinase active center to form a close complex and Hinokitiol CAS 499-44-5 , resulting in the decline of tyrosinase catalytic activity, which is the main way for it to inhibit tyrosinase activity; At the same time, the light groups and ketones on Hinokitiol CAS 499-44-5 can also combine with tyrosinase substrate complex (ES) to form ternary complex, which can regulate the formation of melanin.

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