Felodipine  is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers
Felodipine is a 1,4-dihydropyridine small molecule antagonist and calcium channel protein inhibitor. Antagonism of the vascular L-type (long-lasting) calcium channel decreases intracellular calcium concentration, softening the tone of vascular tissue and  decreasing the peripheral resistance upon the blood stream, effectively decreasing systemic arterial blood pressure without affecting myocardial contractility. Felodipine is described to inhibit cytokine-induced NO and superoxide production as well as cytokine-induced NO synthase (NOS) mRNA induction, and is suggested to act as a scavenger of superoxide and not an inhibitor of inducible NOS induction. This indicates that Felodipine further protects the vasculature against endogenous free radical generation during inflammatory responses.

Application
Used for the treatment of high blood pressure is a selective calcium antagonists, inhibit the main flow of extracellular calcium arterial smooth muscle cells, and selective expansion of small arteries, veins, no such effect, not cause orthostatic hypotension; myocardial also. no significant inhibition. This product reduces renal vascular resistance, while not affect glomerular filtration rate and creatinine clearance rate, renal blood flow did not change even slightly increased, there natriuretic and diuretic effect. It can be used to increase output and cardiac index, significantly reducing afterload, while the systolic function, preload and heart rate had no significant effect.

Packaging & Shipping
1. Inner double plastic bags----25kg/Fiber drum (36*36*45cm, GW: 28kg, NW: 25kg);
2. Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3. Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg, NW: 1kg).
 

Hebei Niuri Spraying Technology Co., Ltd.  It was founded in 2023, located in Xingtai, Hebei Province, which is specialized in the research of production and trade of plastic material and pharmaceutical intermediate. Our products have spread over more than 50 countries in the world, Most of the products produced and sold are exported abroad, and it is well-received in all around the word for its excellent quality. At the same time in case to maintain good relations of cooperation with domestic manufactures, we actively develop new products, new customers and constantly meet the needs of customers at home and abroad. We sincerely welcome more clients to cooperate with us.

1. We have our own factory and produce our own research and development products.
2.The quality of our products is guaranteed and the price is favorable
3.We are relatively close to Tianjin Port, and the delivery is more convenient
4. We can customize according to customer's needs

Q1: Are you a manufacturer or trade company?
A: We are a manufacturer for Powder Coating and Plastic Masterbatches products over 10 years.
OEM & ODM are available.  

Q2: Can I get a sample before order in bulk? What is your MOQ ?
A: Yes, support sample order.   

Q3:What is the lead time?
A: Generally 5-20 days(based on quantity).  

Q4:Where is your loading port? 
A: Tianjin Port, In China.  

Q5.What is the shipping method?
A: It could be shipped by sea,by air or by express(EMS,UPS,DHL,TNT,FEDEX and ect).
Please confirm with us before placing orders.  

Q6:What are your payments terms?
A: T/T, PayPal, Western Union or by Alibaba Trade Assurance  

Q7.How do you make our business long-term and good relationship?
A: 1. We keep good quality and competitive price to ensure our customers' benefit;
    2. We respect every customer as our friend and we sincerely do business and make friends with them, no matter where they come from.