3, 3′ , 5, 5′ -Tetramethylbiphenyl-4, 4′ - Diamine ; CAS 54827-17-7

Colour
Yellow
Samples
Available
Purity
99%
Certificates
ISO9001/SGS
Package
1kg/5kg/10kg/25kg
Stocks
in Stock
Lead Time
5-7 Working Days
Shelf Life
2-3 Years
Site Audit
Available
Transport
Air/Express/Sea
MOQ
10g
Transport Package
Drum/Bottle/Bags
Trademark
Yunbang
Origin
China
Reference Price
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Product Description

3,3',5,5'-Tetramethylbiphenyl-4,4'-diamine;CAS 54827-17-7

3, 3′ , 5, 5′ -Tetramethylbiphenyl-4, 4′ -Diamine; CAS 54827-17-7
 
 
Tetramethylbenzidine Chemical Properties
Melting point  168-171 °C(lit.)
Boiling point  100 °C
density  1
refractive index  1.5519 (estimate)
storage temp.  2-8°C
solubility  Slightly soluble. <0.1 g/100 mL at 20°C.
pka 4.49±0.10(Predicted)
form  tablet
color  Cream
Water Solubility  Slightly soluble. <0.1 g/100 mL at 20 ºC
Sensitive  Light Sensitive
BRN  2808541
Stability: Stable, but moisture sensitive and may be light sensitive. Incompatible with water, strong oxidizing agents.
CAS DataBase Reference 54827-17-7(CAS DataBase Reference)
EPA Substance Registry System 3,3',5,5'-Tetramethylbenzidine (54827-17-7)
Tetramethylbenzidine Usage And Synthesis
Description Tetramethylbenzidine(TMB) is a chromogenic substrate used in staining procedures in immunohistochemistry as well as being a visualising reagent used in enzyme-linked immunosorbent assays (ELISA). It is a white solid that forms a pale blue-green liquid in solution with ethyl ac etate. Tetramethylbenzidine is degraded by sunlight and by fluorescent lights. It is a soluble chromogen substrate for horseradish peroxidase detection systems. Tetramethylbenzidine is recommended for ELISA procedures.
Chemical Properties Tetramethylbenzidine is sensitive to prolonged exposure to light. Neutralizes acids in exothermic reactions to form salts plus water.Tetramethylbenzidine may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Reactions TMB can act as a hydrogen donor for the reduction of hydro gen peroxide to water by peroxidase enzymes such as horseradish peroxidase.

Oxidation of TMB

Shows the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to 3,3',5,5'-tetramethylbenzidine diimine
The resulting diimine causes the solution to take on a blue colour, and this colour change can be read on a spectrophotometer at the wavelengths of 370 and 650 nm.
Carcinogenicity It is not known if Tetramethylbenzidine is carcinogenic and the evidence is contradictory: Tetramethylbenzidine is not mutagenic by the Ames test, and did not induce formation of tumors in a single-arm study of 24 rats. On that evidence, it has been used as a replacement for carcinogenic compounds such as benzidine and o-phenylenediami ne.
storage Keep as concentrated solution, aliquot and store at 4ºC. Do not freeze.
Chemical Properties White or light yellow solid
Uses 3,3,5,5-Tetramethyl benzidine is used as a reagent in a sensitive staining procedure for the detection of low levels of heme-associated peroxidase activity of cytochrome P-450 on SDS-polyacrylamide or agarose gel; non-carcinogenic substitute for benzidine as reagent for the detection of blood and determination of hemoglobin content.
General Description Pale yellow crystals or off-white powder.
Air & Water Reactions Insoluble in water.
Reactivity Profile Tetramethylbenzidine is sensitive to prolonged exposure to light . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard Flash point data for Tetramethylbenzidine are not available, however, Tetramethylbenzidine is probably combustible.
 
3, 3&prime; , 5, 5&prime; -Tetramethylbiphenyl-4, 4&prime; -Diamine; CAS 54827-17-7
 
3, 3&prime; , 5, 5&prime; -Tetramethylbiphenyl-4, 4&prime; -Diamine; CAS 54827-17-7 3, 3&prime; , 5, 5&prime; -Tetramethylbiphenyl-4, 4&prime; -Diamine; CAS 54827-17-7 3, 3&prime; , 5, 5&prime; -Tetramethylbiphenyl-4, 4&prime; -Diamine; CAS 54827-17-7
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. ( Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of P harmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

 

Organic Intermediate