Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil

Model NO.
TY-02ALI
Colour
White
Package
Foil Bag
Place
China
Assay
99%
Shelf
2 Years
Transport Package
25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
Specification
25kg/drum
Trademark
tongyon
Origin
China
Production Capacity
5000kg/Month
Reference Price
Please contact us for quote
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Product Description

Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil
Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil

Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil
 
Product name Candesartan cilexetil
CAS 145040-37-5
Appearance white powder
Assay 99%
Storage Cool and Protect from light


Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil

Candesartan cilexetil
Product Name Candesartan cilexetil

CAS 145040-37-5

MF C33H34N6O6

MW 610.66

EINECS 627-030-2

MOL File 145040-37-5.mol

Chemical Properties

Melting point 168-170?C
Boiling point 843.3±75.0 °C(Predicted)
Density  1.37±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: ≥15mg/mL
form  powder
pka pKa 3.55 (H2O t=25.0 I=0.025) (Uncertain);5.91(H2O t=25.0 I=0.025) (Uncertain)
color  white to beige
λmax 304nm(EtOH)(lit.)
Merck  14,1739
InChIKey GHOSNRCGJFBJIB-UHFFFAOYSA-N
CAS DataBase Reference 145040-37-5(CAS Dat


Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil
Usage And Synthesis
Description

Candesartan cilexetil is a kind of prodrug being hydrolyzed to candesartan during absorption from the gastrointestinal tract. It appears as a white or off-white powder with a molecular weight of 610.67. It is soluble in methanoll but insoluble in water. It is a kind of selective AT1 subtype angiotensin II receptor antagonist, mainly used for the treatment of hypertension and heart failure. Candesartan cilexetil takes effects through selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland, further blocking the vasoconstrictor and aldosterone-secreting effects of angiotensin II. Therefore, its mode of action is not through interfering with the pathways for angiotensin II synthesis. Candesartan cilexetil may lead to various kinds of adverse reactions including headache, back pain, dizziness, upper respiratory tract infection, pharyngitis, rhinitis, bronchitis, coughing, sinusitis, nausea, abdominal pain, diarrhea, vomiting, arthralgia and albuminuria. It should be warned that candesartan cilexetil might have remarkable fetal toxicity. Therefore, upon pregnancy, candesartan cilexetil should be discontinued. It could also cause hypotension for heart-failure patients.

GuangZhou TongYi biochemistry technology Co., Ltd is a company specializing in active pharmaceutical ingredient
(API), biology, plant extracts, chemical raw materials, fine chemicals, pharmaceutical intermediates, cosmetics raw
material. Our company has always adhered to the company philosophy of integrity, professionalism, quality first, and
customer service. With the efforts of all the company's employees, it has established long-term
and stable cooperative relations with many domestic and foreign customers, and won the unanimous trust of domestic
and foreign customers. With good comments, our company have made great progress.

Our company takes pioneering and innovative, high-quality and efficient as the code of conduct, and strives to provide
customers with efficient services,
high-quality products, and reasonable prices. We have established a customer demand-oriented, flexible, diverse and customizable service according to the different needs of different customers. Mode, and ultimately achieve the goal of
win-win.

Our company focuses on the future and the world, and will continue to devote itself to technological progress and the
development of new products in the future, hoping to work hand in hand with new and old friends at home and abroad
to create a better future.

Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil Manufacturer Supply High Quality CAS 145040-37-5 Candesartan Cilexetil

 

Organic Intermediate