D-Tagatos; P-Tagatose; D- (-) -Tagatose; CAS87-81-0

Colour
White
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Purity
99%
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Shelf Life
2-3 Years
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MOQ
10g
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Yunbang
Origin
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Product Description

d-tagatos;P-TAGATOSE;D-(-)-TAGATOSE;CAS87-81-0

D-Tagatos; P-Tagatose; D- (-) -Tagatose; CAS87-81-0
D-TAGATOSE Basic information
Product Name: D-TAGATOSE
Synonyms: d-tagatos;TAGATOSE, D-;TAGLOSE;P-TAGATOSE;D-(-)-TAGATOSE;(2S,3S,4S,5R)-2-(hydroxymethyl)oxane-2,3,4,5-tetrol;D-(-)-Tagatose,mixture of anomers;D-lyxo-2-Hexulose
CAS: 87-81-0
MF: C6H12O6
MW: 180.16
EINECS: 201-772-3
Product Categories: carbohydrate ; Carbohydrates & Derivatives ; Basic Sugars (Mono & Oligosaccharides) ; Biochemistry ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sugars ; Tagatose ; Dextrins,Sugar & Carbohydrates ; Carbohydrate LibraryCarbohydrates ; Carbohydrates ; Carbohydrates A to ; Carbohydrates P-ZBiochemicals and Reagents ; Metabolic Libraries ; Metabolomics ; Monosaccharide
Mol File: 87-81-0.mol
 
 
D-TAGATOSE Chemical Properties
Melting point  130-136 °C
alpha  D25 -5° (c = 1 in water)
Boiling point  232.96°C (rough estimate)
density  1.2805 (rough estimate)
refractive index  -5.5 ° (C=1, H2O)
solubility  H 2 O: 0.1 g/mL, clear, colorless
pka 11.86±0.20(Predicted)
form  neat
optical activity [α]/D -5.8±0.8°, c = 1 in H2O
Merck  14,9030
BRN  1724555
CAS DataBase Reference 87-81-0(CAS DataBase Reference)
 
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  24/25-36-26
WGK Germany  3
RTECS  WW1100000
F  3-10
HS Code  29400000
 
 
D-TAGATOSE Usage And Synthesis
Description D-tagatose is a carbohydrate occurring in small amounts in several foods. The solubility in water is approximately 580 g/L at room temperature. As a ketohexose, tagatose reacts in foods in browning reactions like other ketohexoses, for example, fructose.
Tagatose is, depending on the concentration, approximately 92 % as sweet as sucrose and noncariogenic. The caloric value of tagatose is generally set to 1.5 kcal/g. 
In the European Union, tagatose is approved as a novel food. In the United States, tagatose has GRAS status and it is also approved in many other countries.
Chemical Properties Tagatose is a white, anhydrous crystalline solid. It is a carbohydrate, a ketohexose, an epimer of D-fructose inverted at C-4. It can exist in several tautomeric forms.
Chemical Properties white to off-white crystalline powder
Uses A monosaccharide (hexose) that can be used as a low-calorie sweetener, as an intermediate for synthesis of other optically active compounds, and as an additive in detergent, cosmetic, and pharmaceutical formulation.
Uses Sweetener; bulking agent
Production Methods Tagatose is obtained from D-galactose by isomerization under alkaline conditions in the presence of calcium.
Biotechnological Production Tagatose is produced from galactose, which can be obtained by enzymatic hydrolysis of lactose, the main carbohydrate of milk. Galactose is separated from glucose by chromatography and either isomerized by treatment with calcium hydroxide, subsequent precipitation of calcium carbonate with carbon dioxide, filtration, demineralization with ion exchangers and crystallization [15], or converted enzymatically.
Especially high conversion rates of 96.4 % were obtained with an enzyme extract of an engineered E. coli, and of 60 % at 95 C for A. flavithermus in the presence of borate. Conversion rates of 58 % were reported for an enzyme obtained from a mutant of G. thermodenitrificans [100], of 54 % at 60 C for a recombinant enzyme of Thermus sp. expressed in E. coli, and of more than 50 % at 75 C for E. coli containing an enzyme of A. cellulolytics. 
Immobilized enzymes or whole cells were used for practical applications. In some studies, high yields and productivities were achieved. 
Immobilized L-arabinose isomerase in calcium alginate produced 145 g/L of tagatose with 48 % conversion of galactose and a productivity of 54 g/Lh in a packed-bed reactor. An enzyme of T. mathranii immobilized in calcium alginate had its optimum at 75 C with a conversion rate of 43.9 % and a productivity up to 10 g/Lh with, however, lower conversion. After incubation of the resulting syrup with S. cerevisiae, purities above 95 % were achieved. The enzyme of T. neapolitana immobilized on chitopearl beds gave a tagatose concentration of 138 g/L at 70 C. 
Lactobacillus fermentum immobilized in calcium alginate had a temperature optimum of 65 C. A conversion rate of 60 % and a productivity of 11.1 g/Lh were obtained in a packed-bed reactor after addition of borate. 
Direct production of tagatose in yogurt was possible by expressing the enzyme of B. stearothermophilus in Lactobacillus bulgaricus and Streptococcus thermophilus.
Pharmaceutical Applications Tagatose is used as a sweetening agent in beverages, foods, and pharmaceutical applications. A 10% solution of tagatose is about 92% as sweet as a 10% sucrose solution. It is a low-calorie sugar with approximately 38% of the calories of sucrose per gram. It occurs naturally in low levels in milk products. Like other sugars (fructose, glucose, sucrose), it is also used as a bulk sweetener, humectant, texturizer, and stabilizer, and may be used in dietetic foods with a low glycemic index.
Safety Tagatose is safe for use in food and beverages. It has been used in pharmaceutical products.
storage Tagatose is stable under pH conditions typically encountered in foods (pH>3). It is a reducing sugar and undergoes the Maillard reaction.
Tagatose is stable under typical storage conditions. It caramelizes at elevated temperature.
Purification Methods Crystallise D(-)-tagatose from EtOH/H2O (6:1). It mutarotates from [] 22D +2o (2minutes) to -5.0o (30minutes) (c 4, H2O). The phenylosazone crystallises from aqueous EtOH with m 185-187o(dec), and [] 23D +47o (c 0.82, 2-methoxyethanol). [Totton & Lardy J Am Chem Soc 71 3076 1949, Gorin et al. Canad J Chem 33 1116 1955, Reichestein & Bossard Helv Chem Acta 17 753 1934, Wolfrom & Bennett J Org Chem 30 1284 1965, Beilstein 1 IV 4414.] In D2O at 27o 1H NMR showed the following ratios: -pyranose (79), -pyranose (16), -furanose (1) and -furanose (4) [Angyal Adv Carbohydr Chem 42 15 1984, Angyal & Pickles Aust J Chem 25 1711 1972].
Incompatibilities A Maillard-type condensation reaction is likely to occur between tagatose and compounds with a primary amine group to form brown or yellow-brown colored Amidori compounds. Reducing sugars will also interact with secondary amines to form an imine, but without any accompanying yellow-brown discoloration.
Regulatory Status GRAS listed. Included in the FDA Inactive Ingredients Database (oral and rectal solutions).
 
D-TAGATOSE Preparation Products And Raw materials
 
 
D-Tagatos; P-Tagatose; D- (-) -Tagatose; CAS87-81-0


D-Tagatos; P-Tagatose; D- (-) -Tagatose; CAS87-81-0 D-Tagatos; P-Tagatose; D- (-) -Tagatose; CAS87-81-0 D-Tagatos; P-Tagatose; D- (-) -Tagatose; CAS87-81-0
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd. ( Yunbangpharm) located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines".

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products.
We can perform -100°C to 300°C reaction.

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of P harmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating our brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

 

Organic Intermediate