Function
Galantamine Hydrobromide
is the hydrobromide salt form of
galantamine
, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family with anticholinesterase and neurocognitive-enhancing activities.
Galantamine
competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of
acetylcholine
(Ach).
In addition,
galantamine
is a ligand for nicotinic
acetylcholine
receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors.
This agent may improve neurocognitive function in mild and moderate Alzheimer' s disease and may reduce abstinence-induced cognitive symptoms that promote smoking relapse.