High Purity Meldrum′ S Acid 2033-24-1 Used in Pharmaceutical Intermediate

Model NO.
Hengmai
Colour
White
Transport Package
Barrel or Bag
Specification
25Kg/Barrel or as required
Trademark
Hengmai
Origin
China
Production Capacity
200 Tons/Month
Reference Price
$ 19.80 - 27.00
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Product Description

Product Description
Brief Introduction
Name Meldrum's Acid
Synonyms 2,2-Dimethyl-1,3-Dioxane-4,6-Dione
Isopropylidene Malonate
Malonic Acid Cyclic Isopropylidene Ester
Cyclic Isopropylidene Malonate
CAS 2033-24-1
EINECS 217-992-8
Molecular Formula C6H8O4
Molecular weight 144.13
Pureness ≥99%
Production Capacity 200 tons/month
Density 1.1311 (rough estimate)
Melting Point 92-96°C(lit.)
Boling Point 182.71°C (rough estimate)
Flash Point 150.1°C
Water Solubility 2.5 g/100 mL (20 ºC)
Vapor Presure 0.044-133Pa at 25 ºC
Appearance White crystalline powder
Merck 145817
BRN 117310
pKa 5.1(at 25ºC)
Storage Condition 2-8°C
Refractive Index 1.4434 (estimate)
MDL MFCD00006638
InChI InChI=1S/C6H8O4/c1-6(2)9-4(7)3-5(8)10-6/h3H2,1-2H3
InChIKey GXHFUVWIGNLZSC-UHFFFAOYSA-N
High Purity Meldrum′ S Acid 2033-24-1 Used in Pharmaceutical Intermediate

Product Description
Due to its unique structure and the vast array of substituents that can be attached to its core, Meldrum's acid is a molecule with exceptional chemical properties. In water, it has a remarkably low pKa value of about 4.9. Its C5 position is readily involved in electrophilic substitution reactions whereas the C4 and C6 positions are easily attacked by nucleophiles. At elevated temperatures Meldrum's acid undergoes distinctive decomposition pathways, which can be used in cycloaddition and acylation reactions.  

Solubility
Meldrum's acid or 2,2-dimethyl-1,3-dioxane-4,6-dione is an organic compound with formula . Its molecule has a heterocyclic core with four carbon and two oxygen atoms; the formula can also be written as [−O− (C (CH3)2)−O− (C=O)− (CH2)− (C=O)−]  . It is a crystalline colorless solid, sparingly soluble in water. It decomposes on heating with release of carbon dioxide and aceton e.

Stability

  1. It will not decompose if used and stored according to specifications. No known hazard reactions. Avoid oxides, moisture/moisture.
  2. It ' s very stable and can be stored for a long time at room temperature.
Storage Attentions
Keep the storage device sealed and stored in a cool, dry place. Ensure that the workshop is well ventilated or vented.
Our Advantages
1. It's used as a pharmaceutical intermediate.   The ring (sub) isopropyl malonate can be used as an intermediate in pharmaceutical synthesis, and it can be used to prepare the compound 3-oxo-4-phenylvalerate Ethyl, further preparation of 3, 4-disubstituted-6-phenylethylpyridinone HIV-1 reverse transcriptase inhibitors.
2. It's used in organic synthesis. T he protective reagent   is obtained by aldol condensation and reduction with triethylamin e formaldehyde. the benzyl substituted michele acid is hydrolyzed, lost CO2 and chlorosulfonic acid for Friedel-Crafts cyclization to produce 2, 3-dihydro-2-indanone. Accelerate the Noven Gall concentration reaction between aldehyde and Michaelis acid in ionic liquid (Knoevenagel condensations).
Packaging & Shipping

High Purity Meldrum′ S Acid 2033-24-1 Used in Pharmaceutical Intermediate

High Purity Meldrum′ S Acid 2033-24-1 Used in Pharmaceutical Intermediate

FAQ

When can I get the price?

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your email so that we will regard your inquiry priority.

How can I get a sample to check your quality?

After price confirmation, you can require for samples to check our quality.
If you just need a blank sample to check the design and paper quality, we will provide you sample for free, as long as you afford the express freight.

Can you do the design for us?

Yes. We have a professional team having rich experience in gift box design and manufacturing. Just tell us your ideas and we will help to carry out your ideas into perfect gift boxes. It does not matter if you do not have someone to complete files. Send us high resolution images, your Logo and text and tell us how you would like to arrange them. We will send you finished files for confirmation.

How long can I expect to get the sample?

After you pay the sample charge and send us confirmed files, the samples will be ready for delivery in 3-7 days. The samples will be sent to you via express and arrive in 3-5 workdays. You can use your own express account or prepay us if you do not have an account.

What about the lead time for mass production?

Honestly, it depends on the order quantity and the season you place the order. The best record we keep is delivering 20,000 gift boxes within a week. Generally speaking, we suggest that you start inquiry two months before the date you would like to get the products at your country.

What is your terms of delivery?

We accept EXW, FOB, CFR, CIF, DDU, DDP, etc. You can choose the one which is the most convenient or cost effective for you.



 

 

Organic Intermediate