Product Description
7-Hydroxy Basic information
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Product Name:
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7-Hydroxy
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Synonyms:
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7-Hydroxy Mitragynine;(7α,16E,20β)- 1,2,16,17-Tetradehydro-2,7-dihydro-7-hydroxy-9,17-diMethoxycorynan-16-carboxylic acid Methyl Ester;(αE,2S,3S,7aS,12bS)-3-Ethyl-1,2,3,4,6,7,7a,12b-octahydro-7a-hydroxy-8-Methoxy-α-(MethoxyMethylene)indolo[2,3-a]quinolizine-2-acetic Acid Methyl Ester;7α-Hydroxy-7H-Mitragynine;9-Methoxycorynantheidine Hydroxyindolenine;Mitragynine Hydroxyindolenine;HYDROXYMITRAGYNINE, 7-(SH);7-Hydroxy solution
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CAS:
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174418-82-7
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MF:
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C23H30N2O5
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MW:
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414.49
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EINECS:
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Product Categories:
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Herb extract
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Chiral Reagents
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Heterocycles
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Intermediates & Fine Chemicals
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Metabolites & Impurities
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Pharmaceuticals
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Mol File:
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174418-82-7.mol
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7-Hydroxy Chemical Properties
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Boiling point
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567.4±50.0 °C(Predicted)
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density
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1.29±0.1 g/cm3(Predicted)
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Fp
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2ºC
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storage temp.
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-20°C Freezer
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pka
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12.20±0.60(Predicted)
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Hazard Codes
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F,T
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Risk Statements
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11-23/24/25-39/23/24/25
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Safety Statements
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16-36/37-45
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RIDADR
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UN1230 - class 3 - PG 2 , solution
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WGK Germany
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1
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7-Hydroxy Usage And Synthesis
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Description
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It is a minor constituent of this plant (Ponglux et al., 1994). 7-Hydroxyexhibited a higher potency than mitragynine in the guinea-pig ileum test and a high affinity for A-opioid receptors in binding assays (Takayama et al., 2002).
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Uses
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A metabolite of Mitragynine. Along with mitragynine, 7-Hydroxy is an active alkaloid found in the plant Mitragynine speciosa. The compound possesses opioid agonistic activity with a potentcy 30- and 17-fold higher than that of mitragynine, respectively.
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Preparation
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7-Hydroxy is produced by oxidation of mitragynine and is a minor constituent (< 0.01% in fresh leaves) found at concentrations of up to 2% in leaf extracts and commercial products; however, it is believed to be the major contributor to the known addictive potential of given its activity as a potent μ-opioid receptor agonist.
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Pharmacokinetics
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Mitragynine and 7-hydroxy are partial agonists at the mu-opioid receptor. Human studies demonstrate the analgesic effects of mitragynine and 7-hydroxy have been shown to be antinociceptive in animal models. The antinociceptive effects are reversed by an opioid antagonist.
Mitragynine also binds to adrenergic receptors, serotonergic and dopamine receptors. Although there is limited information regarding its effects at these receptors,mitragynine have been reported in animal studies to have a variety of non-opioid-like behavioural effects, including antidepressant and antipsychotic effects.
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Detailed Photos
Packaging & Shipping
Packing Method:
For small samples quantity <1 kilograms
, inside we use double resealable zip bags and outside with aluminium Foil
Bags. For medium quantity 1-25 kilograms, we pack them in double-layer plastic ziplock bags (inside) with aluminium foil bag(outside). Then packed in cartons or small drums as your requirement via FedEx/TNT/DHL or special channal.
For larger quantity >25
kilograms,
normally we pack them in drums(normally 25KG per) with two strong PET bags.
We do supply smaller packages like 10gram/50gram per bag as your requirement. Please contact us for more details if you have any question!
Shipping Transit could be DHL.UPSTNT EMS Fedex and so on. For mass orders,it will be delivered by air or sea. Depending on your location,please allow 1-5 business days for your order to arrive. For small order please expect 3-7 days by UPS DHL EMS, For mass order,please allow 5-8 days by Air15-30 days by Sea.
Our Advantages
Company Profile
Hebei Mirun Import and Export Trading Co., LTD
Hebei Mirun Import and Export Trading Co., LTD
is a company mainly engaged in high quality organic intermediates and other related
products research and development and sales for the integration of high-tech enterprises. Analysis of testing equipment, our
company has advanced and complete supporting system, formed the advanced chemical synthesis can quickly meet the applicable test
to the industrialized production of personalized requirements and seriation. If you are looking for a reliable supplier,we are the
perfect choice. We are a factory located in China. Provide door to door service. We have our own shipping that are very
professional in custom clearance, you need't to do anything.
FAQ
Q1:Are you trading company or manufacturer?
A1:We are chemical factory in China,So we can provide wholesale price.
Q2:How can I get the samples?
A2:We can provide you free sample for our existing products, the lead time is about 1-2 days. You just need to pay the sample delivery cost.
Q3:If the inspection result can not meet the agreement between the two sides, can you bear all the losses caused by this?
A3:Yes, we can. We guarantee that the samples provided will meet the needs of our clients and we will bear the risk of default.
Q4:How long is your delivery time?
A4:Generally it is with 5 days if the goods are in stock. According to quantity your required, the delivery time may
slightlychange.
Q5:What's your terms of payment?
A5:We can accept various payment methods, western union, T/T, BTC( bitcoin)etc.