Thiazole-5-carboxaldehyde Chemical Properties |
Melting point | 229 °C (decomp) |
Boiling point | 92-94 °C/16 mmHg |
density | 1.304 g/mL at 25 °C |
refractive index | 1.5874 |
Fp | 98 °C |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
pka | 0.94±0.10(Predicted) |
InChIKey | ZXRLWHGLEJGMNO-UHFFFAOYSA-N |
CAS DataBase Reference | 1003-32-3(CAS DataBase Reference) |
Safety Information |
Hazard Codes | Xi,Xn |
Risk Statements | 36/37/38-43-36-22 |
Safety Statements | 26-36/37/39-36/37 |
WGK Germany | 3 |
Hazard Note | Irritant |
HazardClass | IRRITANT |
HS Code | 29341000 |
MSDS Information |
Thiazole-5-carboxaldehyde Usage And Synthesis |
Chemical Properties | White to brown liquid or solid |
Uses | Thiazole-5-carboxaldehyde is used in the synthesis of imidazoles with cardiomyocyte proliferation activity for heart disease treatments. |
Synthesis Reference(s) |
Synthetic Communications, 25, p. 4081, 1995
DOI:
10.1080/00397919508011485
Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146 |
Purification Methods | Dry the aldehyde over Na2SO4 and fractionate it in a vacuum. The 2,4-dinitrophenylhydrazone forms red crystals from MeOH with m 238-240o, and the semicarbazone has m 210-212o (from MeOH). [Erne et al. Helv Chim Acta 34 148 1951, Beilstein 27 III/IV 2615.] |