Items |
Standard |
Result |
Appearance | White to yellowish powder,very hygroscopic. | White powder, hygroscopic |
Identification | Reaction positive | Complies |
Solubility | Freely soluble in water and in methano l | Complies |
Related substance | Individual impurity: Not more than 0.1% | 0.055% |
Total impurities: Not more than 0.4% | 0.17% | |
Aceton e | Not more than 0.5% | Not detected |
Dichloromethan e | Not more than 0.06% | Complies |
Water | Not more than 5.0% | 0.43% |
Heavy metal | Not more than 20ppm | Complies |
Assay (on anhydrous basis) | 99%-101.0% by titration | 99.30% |
Conclusion |
THE MATERIAL CONFORMS WITH THE ENTERPRISE
STANDARD |
Tianepti
ne sodium salt
is a salt of Tianeptine. Tianeptine, a tricyclic compound, is a selective facilitator of 5-HT (serotonin; sc-201146) uptake in vitro and in vivo. Additionally, Tianeptine is reported to act as a selective inhibitor of dopamine uptake . Tianeptine does not have a noted effect on monoamine uptake. In a study utilizing purified synaptosomes from rat brain, Tianeptine was reported to enhance serotonin uptake in selective brain regions. Purified synaptosomes were obtained from rats and incubated with tritium-label
ed 5-HT and Tianeptine in vitro . The synaptosomes were then analyzed for uptake and release of 5-HT via a liquid scintillation.
Tianeptine is antidepressant. The animal has: the hippocampus pyramidal cells increased spontaneous activity, and accelerating its function was inhibited after recovery; increase in cortical and hippocampal neurons at sites of 5- serotonin reuptake. Tianeptine without following adverse effects: sleep and alertness; cardiovascular system; cholinergic system ( without anticholinergic symptoms ); drug craving.
1) Tianeptine Sodium Improves Depressive Symptoms.
2) Tianeptine Sodium Lessens Anxiety, Stress, and PTSD and Symptoms From Stress.
3) Tianeptine Sodium Benefits Memory and Learning.
4) Tianeptine Sodium is an Anti-inflammatory.
5) Tianeptine Sodium decreases pain.
6) Tianeptine Sodium Helps Treat Irritable bowel Syndrome.
7) Tianeptine Sodium Reduces Asthma.