Lanreotide (INN) is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome. It is a long-acting analogue of somatostatin, like octreotide. Its sequence is H-D-2Nal-Cys(1)-Tyr-D-Trp-Lys-Val-Cys(1)-Thr-NH2.
Lanreotide (as lanreotide acetate) is manufactured by Ipsen, and marketed under the trade name Somatuline. It is available in several countries, including the United Kingdom, Australia and Canada, and was approved for sale in the United States by the Food and Drug Administration (FDA) .
Lanreotide is a synthetic analogue of somatostatin, a naturally occurring inhibitory hormone which blocks the release of several other hormones,thyroid-stimulating hormone (TSH). Lanreotide binds to the same receptors as somatostatin, although with higher affinity to peripheral receptors, and has similar activity. However, while somatostatin is quickly broken down in the body (within minutes), lanreotide has a much longer half-life, and produces far more prolonged effects.
Lanreotide is used in the treatment of acromegaly, due to both pituitary and non-pituitary the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States and Canada, lanreotide is only indicated for the treatment of acromegaly. In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma,a rare tumor of the pituitary gland which secretes TSH.
Lanreotide also shows activity against non-endocrine tumors, and, along with other somatostatin analogues, is being studied as a possible general antitumor agent.
In Dec 2014 the US FDA approved lanreotide for the treatment of patients with unresectable, well or moderately differentiated, locally advanced or metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
It is used for polycystic liver disease. It has also been shown that it reduces the volume by 264mls on average.
Name | Lanreotide |
CAS No. | 108736-35-2 |
Sequence | H-D-2-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2 |
Molecular Formula | C 54 H 69 N 11 O 10 S 2 |
Molecular weight | 1096.32 |
Density | 1.323 g/cm 3 |
Boiling Point | 1498.3 °C at 760 mmHg |
Flash Point | 859.9 °C |
Purity | >99% |
Appearance | White power |
Storage temp | Freeze dried at -20ºC, protected from light |
Synonyms | 1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane,cyclic peptide deriv.;1: PN: WO0006185 PAGE: 8 claimed protein;2: PN:EP1118336 SEQID: 2 claimed protein;37: PN: WO0198330 PAGE: 15 unclaimedsequence;3: PN: WO0006185 PAGE: 8 claimed protein;48: PN: US6268342 SEQID: 53claimed protein;Angiopeptin;Autogel;BIM 23014;DC 13-116;Ipstyl;L-Autogel;Lanreotide;Lanreotide Autogel;Somatulin-Autogel;Somatuline Depot; |
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