Product Name: | Thymosin α1 |
Synonyms: | THYMOSIN ALPHA 1;THYMOSIN ALPHA1 BOVINE;THYMOSIN APHA 1;ZADAXIN;Thymosin α1 Acetate;Thymosin αAcetate salt;Thymalfasin Acetate salt;Thymosin α 1 Acetate(Thymalfasin) |
CAS: | 62304-98-7 |
MF: | C129H215N33O55 |
MW: | 3108.32 |
EINECS: | 1592732-453-0 |
Product Categories: | Amino Acid Derivatives;Peptide;Various Peptides;62304-98-7 |
Mol File: | 62304-98-7.mol |
Thymosin α1 Chemical Properties |
Boiling point | 2899.7±65.0 °C(Predicted) |
density | 1.360±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
solubility | It is recommended to reconstitute the lyophilized Thymosin a1 in sterile 18MΩ-cm H2O not less than 100 μg/ml, which can then be further diluted to other aqueous solutions. |
form | A crystalline solid |
color | Sterile Filtered White lyophilized (freeze-dried) powder. |
Stability: |
Lyophilized Thymosin a1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Thymalfasin should be stored at 4°C between 2-7 days and for future use below -18°C.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
InChIKey | NZVYCXVTEHPMHE-WTRFZTBJNA-N |
Description | Thymosin α1 is an immunomodulator peptide formed from the cleavage of prothymosin α. Thymosin α1 inhibits the growth of 5TGM1 mouse and OPM-2, LP-1, and U266 human multiple myeloma cells in vitro but not in vivo . It also increases CD3- and CD28-induced T cell proliferation in C57BL/KaLwRij splenocytes but not in allogeneic mixed lymphocyte reactions using C57BL/KaLwRij and BALB/c splenocyte co-cultures when used at a concentration of 20 μM. Thymosin α1 also inhibits the growth and migration of H1299, NL9980, and L9981 non-small cell lung cancer (NSCLC) cells that express high levels of programmed cell death ligand 1 (PD-L1) but not of A549 and SPC-A-1 NSCLC cells that express low PD-L1 levels. It also decreases the number of metastatic lesions in a L9981, but not an A549, NSCLC mouse xenograft model when administered at a dose of 20 mg/kg per day. Thymosin α1 (200 μg/kg) increases indoleamine 2,3-dioxygenase 1 (IDO1) expression and IL-10 levels and decreases IL-1β and TNF-α production in the lung in a p.Phe508del mutant cystic fibrosis transmembrane conductance regulator ( CFTR F508del/F508del ) mouse model of cystic fibrosis and chronic A. fumigatus infection. |
Uses |
Zadax-in (SciClone).
Thymosin alpha 1 is a peptide naturally occurring in the thymus that has long been recognized for modifying, enhancing, and restoring immune function. Immune enhancing peptide Helps prevent infections such as the common cold or the flu and diseases Reduces inflammation in the body Aids in the removal of acute or chronic infections Has antibacterial, antiviral, and antifungal properties Supports the eradication of unhealthy cells Protects your cells against oxidative stress and damage Inhibits viral replication Improve symptoms associated with chronic fatigue Thymosin alpha 1 has been utilized in the treatment of immunocompromised states and malignancies, as an enhancer of vaccine response, and as a means of curbing morbidity and mortality in sepsis and numerous infections. |
chemical name: | CAS NO: |
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