Description:
Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral
neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or
fibromyalgia (a condition that causes widespread pain).
Funcation:
Duloxetine is a selective serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor. Preclinical studies have shown that duloxetine is a strong inhibitor of neuronal 5-HT and NE reuptake, and the inhibitory effect on dopamine reuptake is relatively weak. In vitro studies have shown that duloxetine has no significant affinity for
dopaminergic receptors, adrenergic receptors, cholinergic receptors, histamine receptors, receptors, glutamate
receptors, and GABA receptors. Duloxetine does not inhibit monoamine oxidase
1. For the treatment of severe depression, can effectively treat depression and emotional and physical symptoms
2. For diabetic peripheral neuropathic pain.
3. For women with moderate to severe stress urinary incontinence.
Packing and storage:
In 25kg, 50kg, 1000kg net bags, store at a cool, dry and well ventilated place.
Product Name | Duloxetine hydrochloride |
CAS | 136434-34-9 |
Purity | 99% |
Items |
Specification |
Characteristics |
White or almost white crystalline powder, Slightly soluble in water, freely soluble in formicacid,slightly soluble in anhydrous ethanol. |
Melting point |
about 230°C |
Identification |
1) should conformed 2) specific rotation: -17.5° to -20.5° 3) examine by infrared absorption spectrophotometry,compare the spectrum obtained with reference spectrum:should meet the requirements 4) should conformed |
Related substances |
Method A (EP method): Largest single impurity should ≤0.1% Method B(EP method): Largest single impurity should≤0.1% Total impurities should ≤0.2% |
Enantiomeric purity |
≤0.1% |
Heavy metals |
≤20ppm |
Loss on drying |
≤0.5% |
Sulphated ash |
≤0.1% |
Assay |
98.5% ~ 101.0% |
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