Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.

MSA powder is indicated for the treatment of lead poisoning in children with blood levels measured above 45 µg/dL. The use of DMSA is
not approved for prophylactic/prevention of lead poisoning in anticipation of exposure in known lead-contaminated environments. Its elimination
half-life is 2.5-3.5 h. DMSA can cross the blood-brain barrier of mice, but not that of humans, limiting its use to extracting heavy metals from parts
of the body other than the central nervous system.

Another application for DMSA is for the provocation of tissue-heavy metals in anticipation of a urine test. This is sometimes called a "challenge" or
"provoked" heavy metals test. DMSA is used to help mobilize heavy metals stored in body tissues (and therefore not typically present in the circulation) and increase the excretion of heavy metals in the urine. In a study by Howard Frumkin et al., this sort of test was shown to not reliably provide an indication of past chronic exposure, something it was often used for. A 2004 study by GP Archbold, et al. called the results of a DMSA challenge test "misleading" for the purposes of diagnosing  toxicity. Moreover, DMSA shares the limitation of extracellular distribution, which makes it unable to cross the cell membrane and chelate heavy metals from intracellular sites.

The relative activities of a series of novel monoalkyl esters of meso-2,3-dimercaptosuccinic acid (DMSA) have been examined as agents for the
mobilization of c admium, lead owing to the ability of these monoesters to cross cell membranes. The monoesters were found to be
more effective than the parent compound DMSA.

Product Name: DMSA; Succimer

CAS: 304-55-2

Wuhan Quanjinci New Material Co., LTD. is located in Wuhan, Hubei Province, China. We mainly produce ketones, alcohols, organic acids, caine and other fine chemicals and organic chemical raw materials. Products are exported to North America, Europe, Australia, Middle East and other regions. At the same time, we can also provide customers with product customization services.

Our factory covers an area of approximately 3,800 square meters. The first-class R&D team, professional production team, and strict quality inspection department make us a leader in the domestic chemical industry.

Our factory has been developing vigorously, and the production capacity has been rising constantly, which can meet the demands of customers more and faster. Even for large orders, we can complete production in 2-3 weeks. We have professional sales staff, experienced logistics team and patient and meticulous after-sales service to help you solve problems in the order process.

Choosing us, you will have a reliable partner, high-quality products, fast and safe transportation, and worry-free after-sales experience. Sincerely hope that we can establish long-term cooperative relations with our customers and achieve a win-win situation.

1. Quality
Our products meet msds safe standard and we have iso and other certificate so yan can get high quality products from our company.

2.  Price
We are the company which is the joint of trade and industry so we cao provide the competitive price and high quality product.

3. Packing
We can do according to the customers' request.

4. Transport
EMS, DHL, TNT, UPS ,FEDEX, by air, by sea
DHL express, FEDEX and EMS for quantity less than 50kg, usually called as ddu service; 
sea shipping for quantity over 500kg; and air shipping is available for 50kg above;
for high value products, please select air shipping and DHL express for safe;

5. Service
we offer specialized logistic service including export declaration,customs clearance and every detail during shipment,this makes us able to offer you one-stop service from the order to the products transported to your hand.

Q1: Can you supply samples?
Yes, we can provide some free sample, but the shipping cost should be on the customers' account. You can either pay the shipping cost or arrange a courier to collect the samples.
Q2:What's the MOQ?
Differentiate according to the product value,1 gram or 50 kilograms and 100 kilograms.
Q3. How can I release the payment to you ?
We can receive your payment by T/T, ESCROW or Western union which is recommended, and we can also receive by L/C at sight.
Q4:How about delivery leadtime ?
About 3-5 working days after receipt of  your payment.
Q5:Is there a discount?
Yes, for large quantity, we always support with better price
Q6:How do you treat quality complaint?
A: First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q7:How to confirm the Product Quality before placing orders?
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests.