Phe-nacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phe-nacetin-caffei compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phe-nacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result, some branded, previously phe-nacetin-based preparations continued to be sold, but with the phe-nacetin replaced by safer alternatives. A popular brand of phe-nacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffei. Coricidin was also reformulated without phe-nacetin. Paracetamol is a metabolite of phe-nacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phe-nacetin's carcinogenicity.