CAS No.:                4449-51-8
Molecular formula:       C ₂₇ H ₄₁ NO ₂
Molecular weight:         411.62
Melting point:        237-238 ºC
Specific optical Rotation : [ α ] ^{20 ºC} _D   -44.2 º
Product Specification      98%   Cyclopamine (11-deoxojervine)
Product Introduction
Cyclopamine (11-deoxojervine) is a naturally-occurring chemical that belongs to the group of steroidal jerveratrum alkaloids. It is a teratogen isolated from the corn lily ( Veratrum californicum ) that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes ( holoprosencephaly ) and cause the development of a single eye ( cyclopia ). It does so by suppressing the   hedgehog gene   (Hh). Cyclopamine is useful in studying the role of Hh in normal development, and as a potential treatment for certain cancers in which Hh is overexpressed.
Physical Properties :         
White Powder; Odorless; Melting point : 237-238 ºC ; Solubility : 5mg · ml-1 Methanl ; 10mg · ml-1DMF.
Loss on drying:    ≤ 0.5%  

Physiological Functions & Applications
Cyclopamine inhibits the   hedgehog signaling pathway   (Hh) by influencing the balance between the active and inactive forms of the   Smoothened   protein.Cyclopamine is currently being investigated as a treatment agent in   basal cell carcinoma ,   medulloblastoma , and   rhabdomyosarcoma , tumors that result from excessive Hh activity   [2] ,   glioblastoma , and as a treatment agent for   multiple myeloma .

Henan Xiaguo Bio Co.,Ltd is a foreign trading company, specializing in developing and producing a variety of chemicals and pharmaceutical intermediates. We have our own factory, which procures itself a competitive edge in the market. Through years of efforts, it has earned a fabulous reputation all over the world. Also, we've won many clients' support and trust because we always strive to produce high-quality merchandise with favorable price. Thus we are applauded by a lot of sincere recognition from our clients. Faced with so much achievement, Xiaguo still endeavors to make breakthrough in this industry. It aims to produce the best products and to satisfy every customer with its professional service and attitude. We are looking forward to cooperating with you and having a win-win relationship with you. Please rest assured that we will satisfy you.
 

1. who are we?
We are based in Henan, China, start from 2023,sell to Central America(55.00%),North America(45.00%),South America(45.00%),Mid East(45.00%),Western Europe(45.00%),Southern Europe(45.00%),Southeast Asia(35.00%),Africa(35.00%),Eastern Europe(33.00%),Northern Europe(33.00%),Oceania(25.00%),Eastern Asia(25.00%),Domestic Market(22.00%),South Asia(15.00%). There are total about 50 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3. why should you buy from us not from other suppliers?
a. We can offer you favorable prices and guarantee the quality of the products.
b. We have professional production and r&d team.

4. what services can we provide?
Accepted Delivery Terms: FOB,CFR,CIF,EXW,FAS,CIP,FCA,CPT,DEQ,DDP,DDU,Express Delivery,DAF,DES;
Accepted Payment Currency: USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
Accepted Payment Type: T/T,L/C,D/P D/A,MoneyGram,Credit Card,PayPal,Western Union,Cash,Escrow;
Language Spoken: English,Chinese,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian