Bestatin; Ubenamix, Inobestin , Nk 421; CAS 58970-76-6

Colour
White
Samples
Available
Purity
99%
Certificates
ISO9001/SGS
Package
1kg/5kg/10kg/25kg
Stocks
in Stock
Lead Time
5-7 Working Days
Shelf Life
2-3 Years
Site Audit
Available
Transport
Air/Express/Sea
MOQ
10g
Transport Package
Drum/Bottle/Bags
Trademark
Yunbang
Origin
China
Reference Price
Please contact us for quote
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Product Description

Bestatin;UbenaMix, Inobestin, NK 421;CAS 58970-76-6
  Bestatin; Ubenamix, Inobestin, Nk 421; CAS 58970-76-6
 
Bestatin Chemical Properties
Melting point  245 °C (dec.)(lit.)
alpha  D20 -15.5° (c = 1.0 in 1N HCl)
Boiling point  448.76°C (rough estimate)
density  1.0917 (rough estimate)
refractive index  1.5800 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
pka 8.1, 3.1(at 25ºC)
form  Powder
color  White
optical activity [α]20/D 11°, c = 1 in 1 M NaOH
Water Solubility  Soluble in water (<1 25), DMSO (2 mg/ml), met hanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl ace tate, benzene, hexa ne, and chl oroform.
Merck  13,9910
InChIKey VGGGPCQERPFHOB-RDBSUJKOSA-N
CAS DataBase Reference 58970-76-6(CAS DataBase Reference)
 
Safety Information
Safety Statements  22-24/25
WGK Germany  3
RTECS  OH2915000
HS Code  29242998
Toxicity LD50 in male, female mice, male, female rats (g/kg): 1.3, 1.9, 1.9, 2.1 s.c.; 0.19, 0.19, 0.90, 0.78 i.p.; >4.0, >4.0, >2.0, >2.0 orally (Sakakibara)
Bestatin Usage And Synthesis
Description Ubenimex is an immunostimulant useful in the treatment of non-lymphocytic leukemia. In other types of cancers ubenimex added to radiotherapy or chemotherapy following surgery significantly inmases survival time through immunopotentiation.
Chemical Properties white powder
Originator Inst. of Microbial Chem (Japan)
Uses Ubenimex is a competitive aminopeptidase B inhibitor with an IC50 of 100 mg/ml for K562 cells. Proliferation of all the cell lines except KG1 was inhibited by bestatin. P39/TSU, HL60 and U937 were highly sensitive, with 50% growth inhibitory concentration
Uses Bestatin is "pseudo"-dipeptide isolated from Strepotmyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits good antitumour activity and is has been investigated in clinical trials.
Uses Bestatin is "pseudo"-dipeptide isolated from Streptomyces olivreticuli in 1976. Bestatin is a potent aminopeptidase B inhibitor with no carboxypeptidase activity. Bestatin acts as an immunomodulator by activating macrophages and T lymphocytes. Bestatin also exhibits antitumor activity and has been investigated in clinical trials.
Brand name Bestatin
Biological Activity Aminopeptidase inhibitor (K i = 0.001-90 mM); inhibits enkephalin metabolism and leukotriene A 4 hydrolase. Inhibits tumor cell proliferation.
Safety Profile Poison by intraperitoneal route.Moderately toxic by subcutaneous route. Experimentalreproductive effects. When heated to decomposition itemits toxic fumes of NOx.
 
Bestatin; Ubenamix, Inobestin, Nk 421; CAS 58970-76-6 Bestatin; Ubenamix, Inobestin, Nk 421; CAS 58970-76-6 Bestatin; Ubenamix, Inobestin, Nk 421; CAS 58970-76-6
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd.  ( Yunbangpharm)  located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines". 

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products. 
We can perform -100°C to 300°C reaction. 

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of  P harmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating  our  brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

 

Organic Intermediate