Brief Introduction | |
Product name | 4-Nitrobenzyl Alcohol |
Synonyms |
p-Nitrobenzyl alcohol
4-Nitro-benzenemathanol (4-nitrophenyl)methanol 4-(Hydroxymethyl)nitrobenzene 1-Hydroxymethyl-4-nitrobenaene p-nitro-benzyl-alcohol |
CAS | 619-73-8 |
Molecular Formula | C7H7NO3 |
EINECS | 210-611-6 |
Molecular Weight | 153.14 |
Properties | |
Density | 1.3585 (rough estimate) |
Melting Point | 92-94°C(lit.) |
Boling Point | 185°C12mm Hg(lit.) |
Flash Point | 180 °C |
Water Solubility | Soluble in water (2 mg/ml at 20°C). |
Solubility | 2g/l |
Vapor Presure | 0.000128mmHg at 25°C |
Appearance | Crystalline Powder |
Color | Yellow |
BRN | 1424026 |
Refractive index | 1.5030 (estimate) |
pKa | 13.61±0.10(Predicted) |
Storage Condition | Sealed in dry,Room Temperature |
Refractive Index | 1.5030 (estimate) |
Properties | Soluble in ethanol, ether, slightly soluble in water. |
Use | Used as an intermediate in organic synthesis |
InChI | InChI=1/C7H7NO3/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4,9H,5H2 |
InChIKey | JKTYGPATCNUWKN-UHFFFAOYSA-N |
Usage And Synthesis | |
Chemical Properties | light yellow crystal powder |
Usage 1 | 4-Nitrobenzl alcohol is a potential building block in the synthesis of various pharmaceuticals. |
Usage 2 | 4-nitrobenzyl alcohol is used as the sole source of carbon and nitrogen to study the pathway for the catabolism of 4-nitrotoluene by Pseudomonas. |
Definition | 4-nitrobenzyl alcohol is a member of the class of benzyl alcohols that is benzyl alcohol substituted at the para-position by a nitro group. It has a role as a xenobiotic metabolite. It is a member of benzyl alcohols and a C-nitro compound. |
Purification Method | Crystallise the alcohol from EtOH and sublime it in vacuo. Purity should be at least 99.5%. Sublimed samples should be stored in the dark over anhydrous CaSO4 (Drierite). If the IR contains OH bands, then the sample should be resublimed before use. |
Synthesis Method | Dissolve 218g of p-nitrobenzyl acetate in 500ml of hot methanol, stir, and slowly add 380g of 15% sodium hydroxide solution. After adding, place for 5min, pour into ice water to precipitate. The filtered precipitate was decolorized and recrystallized in hot water with activated carbon to obtain 110-121 g of p-nitrobenzyl alcohol. |
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Xinxiang Juyuan Biological Technology Co., Ltd. is specialized in the manufacture, research and development of pharmaceutical intermediates and fine chemicals, such as Biapenem, and series intermediates of Penem.
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