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Ivabradine Hydrochloride; CAS 148849-67-6

Colour
White
Samples
Available
Purity
99%
Certificates
ISO9001/SGS
Package
1kg/5kg/10kg/25kg
Stocks
in Stock
Lead Time
5-7 Working Days
Shelf Life
2-3 Years
Site Audit
Available
Transport
Air/Express/Sea
MOQ
10g
Transport Package
Drum/Bottle/Bags
Trademark
Yunbang
Origin
China
Reference Price
Please contact us for quote
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Product Description

Ivabradine hydrochloride;CAS 148849-67-6
 
Ivabradine Hydrochloride; CAS 148849-67-6
Ivabradine hydrochloride Chemical Properties
Melting point  193-196?C
alpha  58921 +7.8°; 36521 +27.8° (c = 1% in DMSO)
storage temp.  2-8°C
solubility  H2O: ≥5mg/mL (warmed)
form  powder
color  white to beige
optical activity [α]/D +5 to +9°, c = 1 in DMSO
Merck  14,5247
InChIKey HLUKNZUABFFNQS-ZMBIFBSDSA-N
CAS DataBase Reference 148849-67-6(CAS DataBase Reference)
 
Safety Information
Hazard Codes  N
Risk Statements  50/53
Safety Statements  60-61
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
 
MSDS Information
 
 
Ivabradine hydrochloride Usage And Synthesis
Description In an effort to develop angina agents without the unwanted negative inotropic and hypotensive effects associated with b-adrenergic blockers and calcium channel blockers, a new class of heart-rate reducing compounds that act specifically on the sinoatrial (SA) node has been explored. These bradycardic agents interact directly with the pacemaking cell of the SA node and the hyperpolarization- activated If , the primary pacemaking current. Ivabradine has evolved as a specific inhibitor of If current through its contact with f-channels on the intracellular side of the plasma membrane. As a consequence, ivabradine reduces the speed of diastolic depolarization and decreases heart rate. It has been approved for the treatment of chronic stable angina and provides a viable alternative to patients with a contraindication or intolerance of b-blockers. Evaluation is also underway for the potential treatment of ischemic heart disease. Using a patch-clamp technique on rabbit sinoatrial node cells, inhibition of If current ranged from 6% (0.03 mM) - 80% (10 mM). .
Chemical Properties White to Off-White Solid
Originator Servier (France)
Uses Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal
Uses Ivabradine HCl, a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent
Uses angina therapeutic
Definition ChEBI: A hydrochloride obtained by combining ivabradine with one molar equivalent of hydroc hloric acid. Used to treat patients with angina who have intolerance to beta blockers and/or heart failure.
Brand name Procoralan
 
 
Ivabradine Hydrochloride; CAS 148849-67-6 Ivabradine Hydrochloride; CAS 148849-67-6 Ivabradine Hydrochloride; CAS 148849-67-6
Company Informations:

Hunan Yunbang Pharmaceutical Co., Ltd.  ( Yunbangpharm)  located in Changsha High-tech Industrial Park, Hunan. It is a high-tech enterprise specializing in the research and development, production and sales of Pharmaceutical raw materials, Pharmaceutical intermediates(API) and Fine chemicals. Based in China, Yunbangpharm has been providing suitable solutions for many domestic,foreign pharmaceutical companies and traders. Excellent quality, good reputation and authentic price have won the praise of the majority of customers.
The company adheres to the corporate tenet of "We do not produce medicines, but help pharmaceutical companies make good medicines". 

We can provide customers with customized processing, research and development services;
We can develop high-end Pharmaceutical and chemical products with high technical difficulties,high barriers and unique production processes;
We can provide 100 grams Grade, kilograms, and hundred kilograms of raw material pharmaceutical intermediates and other products. 
We can perform -100°C to 300°C reaction. 

R&D strength is the company's core competitiveness.Yunbangpharm has maintains a good cooperation relationship with many Universities and Research institutes locally, which can quickly transform R&D results into industrial production.

Our goal : To achieve the integrated upgrade of  P harmaceutical intermediates, raw materials and high-end chemical products, adhere to "serving pharmaceutical companies, creating  our  brands" to provide customers with high-quality and low-cost pharmaceutical and chemical products, realizing Win-win cooperation and common development.

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