New 7, 8 Dhf Raw Powder 4′ -DMA 7, 8-Dihydroxyflavone/4′ -DMA-7, 8-Dhf Hbr Powder CAS 1205548-00-0

Model NO.
4-DM-7, 8-DHF
Colour
Yellow
MW
297.3053
Safety Precautions
Keep Away From Heat and Fire.
Application
Pharmaceutical Intermediates
Transport Package
25kg/Drum
Specification
99%
Trademark
Shuer
Origin
Wuhan, China
HS Code
300120001
Production Capacity
100tons/Month
Reference Price
$ 55.80 - 66.60
Contact Us

Product Description

Product Name: 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide
Synonym: 4'-DiMethylaMino 7,8-Dihydroxyflavone HydrobroMide;4'-DiMethylaMino 7,8-Dihydroxyflavone; 4'-DMA-7,8-DHF*HBr;4-DM-7,8-DHF;4-DMA-7,8-DHF;4'-DMA-7,8-DHF Free Base
CAS: 1205548-00-0
MF: C17H15NO4
MW: 297.3053
Appearance: Yellow powder
Package: 1kg/ Bag 25kg/drum Or By Request Of Clients
Storage: Cool Dry Place

What is 4'-DMA-7,8-DHF ?

7,8-dihydroxyflavone (7,8-DHF) is a synthetic flavonoid that was initially discovered in a study screening for small molecules that could activate a particular receptor known as tropomyosin-related kinase B (TrkB), because the peptide produced in the human body that acts on this receptor, called brain derived neurotrophic factor (BDNF), could not be used due to poor absorption into the brain. 7,8-DHF was found to be a potent mimic of BDNF able to act on TrkB in a similar manner. This means that 7,8-DHF could theoretically cause similar effects as BDNF in the brain, and in theory be more therapeutically useful due to its better absorption and ability to cross the blood-brain barrier.

Function:

7,8-Dihydroxyflavone (7,8-DHF) is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF).
7,8-DHF is both orally bioavailable and able to penetrate the blood-brain barrier. A prodrug of 7,8-DHF with greatly improved potency and pharmacokinetics, R7, is under development for the treatment of Alzheimer's disease.

7,8-DHF has demonstrated remarkable therapeutic efficacy in animal models of a variety of central nervous system disorders, including depression, Alzheimer's disease, cognitive deficits in schizophrenia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, traumatic brain injury, cerebral ischemia, fragile X syndrome, and Rett syndrome.
7,8-DHF also shows efficacy in animal models of age-associated cognitive impairment and enhances memory consolidation and emotional learning in healthy rodents.

In addition, 7,8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.


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FAQ
Q1: Are you a manufacturer?
A: Yes, We manufacture bulk products in our factory located in Huangmei, Hubei, and produce small quantity and customer synthesis products in our lab located in Wuhan.

Q2: Do you have stock?
A: We understand most customers prefer stock, so we'll try to keep stock for most products. However, for some rare products, we won't keep stock and it needs time to synthesize.

Q3: What certificates and documents do you offer?
A: Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

Q4: Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over 5 years, in average.Strict quality control-comes form our sophisticated management system.
Professional and warm sales team-since we believe we can only win via our hard work in a competitive world
Quick response and excellent presale and after sale service-since we believe our customers deserve all the best service.

Q5: Can I get best price from you?
A: Of course. We don't chase excessive profits and always try tp give best offer. If you are good at bargaining, you can also enjoy fun of bargaining. Just don't make it too hard!

Q6: How should I pay?
A: We accept all kinds of payment ways. such as Credit card, Visa, T/T, West union, MoneyGram
New 7, 8 Dhf Raw Powder 4′ -DMA 7, 8-Dihydroxyflavone/4′ -DMA-7, 8-Dhf Hbr Powder CAS 1205548-00-0
New 7, 8 Dhf Raw Powder 4′ -DMA 7, 8-Dihydroxyflavone/4′ -DMA-7, 8-Dhf Hbr Powder CAS 1205548-00-0 New 7, 8 Dhf Raw Powder 4′ -DMA 7, 8-Dihydroxyflavone/4′ -DMA-7, 8-Dhf Hbr Powder CAS 1205548-00-0 New 7, 8 Dhf Raw Powder 4′ -DMA 7, 8-Dihydroxyflavone/4′ -DMA-7, 8-Dhf Hbr Powder CAS 1205548-00-0

 

Organic Intermediate