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Organic Intermediate
Manufacturer Supply High Quality CAS 2447-57-6 Sulfadoxine
Model NO.
TY-02ALI
Colour
White
Package
Foil Bag
Place
China
Assay
99%
Shelf
2 Years
Transport Package
25kg/Drum 5g, 100g, 500g, 1kg, 10kg, 100kg, 200kg
Specification
25kg/drum
Trademark
tongyon
Origin
China
Production Capacity
5000kg/Month
Reference Price
Please contact us for quote
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Description
Product Description
Product name
Sulfadoxine
CAS
2447-57-6
Appearance
white powder
Assay
99%
Storage
Cool and Protect from light
Product Name:Sulfadoxine
CAS:2447-57-6
MF:C12H14N4O4S
MW:310.33
EINECS:219-504-9
Mol File:2447-57-6.mol Melting point:190-194°C
Boiling point:298°C (rough estimate)
Density 1.4006 (rough estimate)
refractive index 1.6270 (estimate)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml
form powder
The efficacy of sulphadoxine for the treatment of human malaria was first reported in 1964 [1]. Soon thereafter it was found that potentiation took place when sulphadoxine was combined with pyrimethamine for treatment of malaria and monotherapy was abandoned.
Malaria parasites synthesize their folate co-factors and cannot use dietary folic acid as the human host can. Sulphadoxine competes with para-aminobenzoic acid (PABA) for binding to the enzyme dihydropteroate synthetase in the synthesis of dihydropteroate which is an essential substance for the formation of folic acid [2]. It is active against asexual blood forms of P. falciparum but less active against other species. The action is too slow to be used alone for malaria treatment
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