Synonyms:
4-(diphenylmethyl)-1-piperazinyl)ethylmethylester,dihydrochloride;
cv-4093dihydrochlorde;
franidipinehydrochloride;

Chemical & Physical Properties:
Appearance: White to pale yellow solid
Assay :≥99.00%
Boiling Point: 722ºC at 760 mmHg
Melting Point211ºC (dec.)
Water Solubility: Soluble in DMSO. Slightly soluble in water and ethanol /n
Storage: Refrigerator
Solubility: DMSO (Sparingly, Heated), Methanol (Slightly)

Safety Information:
HS Code: 2942000000
RIDADR: UN 2811 6.1/PG III
RTECS: US7975300
Hazard Class: 6.1
Packing Group: III

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties. Manidipine 2Hcl (CV-4093) is a dihydropyridine compound and a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM. IC50 value: 2.6 nMTarget: calcium channelManidipine is described to block T-type Ca2+ channels specifically and is also described to have a high selectivity for the vasculature, presenting negligible cardiodepression as compared to other Ca2+ channel antagonists. Manidipine is also described to not significantly affect norepinephrine levels, suggesting a lack of sympathetic activation with this compound. Manidipine reduces pro-inflammatory cytokines secretion in human endothelial cells and macrophages. Manidipine, unlike other third-generation dihydropyridine derived drugs, blocks T-type calcium channels present in the efferent glomerular arterioles, reducing intraglomerular pressure and microalbuminuria.

Hebei Niuri Spraying Technology Co., Ltd.  It was founded in 2023, located in Xingtai, Hebei Province, which is specialized in the research of production and trade of plastic material and pharmaceutical intermediate. Our products have spread over more than 50 countries in the world, Most of the products produced and sold are exported abroad, and it is well-received in all around the word for its excellent quality. At the same time in case to maintain good relations of cooperation with domestic manufactures, we actively develop new products, new customers and constantly meet the needs of customers at home and abroad. We sincerely welcome more clients to cooperate with us.

1.Place of Origin China with Super quality by reasonable price.                                                  
2.Fast delivery by safe express way to all the country.                                                          
3.Has a number of highly qualified engineers and experts to provide guidance for reagents.    
4.When you meet problems in mineral processing, we can provide technical guidance.                    
5.We can supply sample for testing.                                                                                                
6.We promise 100% deliveried,and 100% resend or refunds if parcel is not deliveried!

Q: Are you trading company or manufacturer ?
A: We are factory.
Q: How long is your delivery time?
A: Generally it is 5-10 days if the goods are in stock. or it is 15-20 days if the goods are not in stock, it is according to quantity.
Q: Do you provide samples ? is it free or extra ?
A: Yes, we could offer the sample for free charge but do not pay the cost of freight.
Q: What is your terms of payment ?
A: Payment<=1000USD, 100% in advance. Payment>=1000USD, 30% T/T in advance ,balance before shippment.
If you have another question, pls feel free to contact us as below.