Product Name | Phenolphthalein |
Synonyms | LABOTEST-BB LT02090809;CI 764;CI NO 764 (1924);BETZ 0212;3,3-BIS(4-HYDROXYPHENYL)-1(3H)-ISOBENZOFURANONE;3,3-Bis(4-hydroxyphenyl)phthalide;3,3-BIS(P-HYDROXYPHENYL)PHTHALIDE;TIMTEC-BB SBB008868 |
CAS | 77-09-8 |
MF | C20H14O4 |
MW | 318.32 |
EINECS | 201-004-7 |
Phenolphthalein
Picture
Items
|
Specifications
|
Characteristics
|
White powder
|
Identification
|
A: Positive
B: Positive |
Appearance of Solution
|
The Solution Is Clear And Not More Intensely Coloured Than Reference Solution Y7
|
Melting Point
|
It melts at about 260ºC
|
Related Substances
|
0.5% max
|
Heavy Metals
|
10ppm max
|
Acidity or Alkalinity
|
Complies
|
Chlorides
|
100ppm max
|
Sulphates
|
200ppm max
|
Loss on Drying
|
0.5% max
|
Sulphated ash
|
0.1% max
|
Assay
|
98.0-101.0%(C20H14O4)
|
Phenolphthalein Function
Phenolphthalein is a chemical that is commonly used as a colorimetric pH indicator. The compound has been observed to turn orange at pH <0, clear between pH 0-8.2, fuchsia between pH 8.2-12, and clear again at a pH above 12. It has been postulated that the mutagenic effects of Phenolphthalein at high doses can be attributed the enhancement intracellular free oxygen radicals. The compound has also been observed to induce mitotic abnormalities and micronuclei with kinetochores in vitro. In Syrian hamster embryos treated with 10-40 μM of Phenolpthalein a significant number of chromosomal aberrations occurred at the hprt locus. On human breast cancer cells Phenolphthalein has been observed to have weak estrogenic effects.
Uses: acid-base indicator, chromatography reagents, organic synthesis, pharmaceutical industry (such as the manufacture of laxatives)