Tfa CAS No. 76- 05-1

Model NO.
76- 05-1
Colour
Colorless
Reaxys Rn
742035
Beilstein
742035
Transport Package
1kg 5kg 10kg 25kg Customizable
Specification
Customizable
Trademark
Sincere Chemicals
Origin
China
HS Code
2915900090
Production Capacity
6000 Tons/Year
Reference Price
$ 8.10 - 9.00
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Product Description

Experimental characteristics
Merck: 9681
Refractive index: 1.2850
Water solubility:  miscible
Boiling point:  72-73 °c
Melting point:  -15.4 °c
Vapor pressure: 97.5 mmHg (20 °C)
Flash point:  Fahrenheit: >212 °F
Celsius:  >100 °C
Solubility:  Miscible with ether, acetone, ethanol, benzene, hexane, and CCl4
Color and properties: colorless, transparent hygroscopic fuming liquid, strong pungent odor.
PH: 1 (10g/l, H2O)
Stability: Stable. Incompatible with combustible material, strong bases, water, strong oxidizing agents. Non-combustible. Hygroscopic. May react violently with bases.
Solubility: soluble in water, ethanol, ether, acetone, benzene.
Sensitivity: Sensitive to humidity
Acidity coefficient (pKa): -0.3 (at 25°C)
Density: 1.4890


Use
First, the product is a good solvent for many organic compounds, combined with carbon disulfide, can dissolve proteins. It is also an excellent solvent for organic reactions. Results that are difficult to obtain in general organic solvents can be obtained.
Second, trifluoroacetic acid is an important reagent for organic synthesis, by which it can synthesize various fluorinated compounds, pesticides and dyes. Trifluoroacetic acid is also a catalyst for esterification and condensation reactions; It can also be used as a protective agent for hydroxyl and amino groups for the synthesis of sugars and peptides.
Third, trifluoroacetic acid (TFA) is a commonly used organic acid in chemical laboratories, because the carboxyl group ortho-carbon is connected with 3 relatively strong electronegative group fluorine atoms, so the nucleophility of carboxylate is greatly reduced, so trifluoroacetic acid is often used as a solvent to study the solvent effect of the reaction. Trifluoroacetic acid has a relatively low boiling point, good volatility, and strong acidity, so it can catalyze many acid-catalyzed chemical reactions, and post-treatment is relatively easy and can be removed by vacuum distillation. In addition, trifluoroacetic acid can participate in oxidation reactions, reduction reactions, rearrangement reactions and deprotection groups.
Fourth, used as a test reagent, solvent, catalyst and for organic synthesis.


Production method
First, it was prepared by oxidation of 2,3-dichlorohexafluoro-2-butene;
Second, 2,3-dichlorohexafluoro-2-butene was oxidized with fluorine as a catalyst to prepare it;
Third, trifluoroacetic acid can be prepared by oxidation of 3,3,3-trifluoropropene by potassium permanganate, or by the reaction of trichloroacetonitrile with hydrogen fluoride to generate trifluoroacetonitrile and then hydrolysis, or electrochemical fluorination of acetic acid (or acetic anhydride). Refining method: distillation and refining under a stream of nitrogen. Or add phosphorus pentoxide to reflux and distill. Further purification can be crystallized in steps followed by distillation.
Fourth, trifluoroacetic acid can be prepared by oxidation of 3,3,3,-trifluoropropene by potassium permanganate; or by the reaction of trichloroacetonitrile and hydrogen fluoride, trifluoroacetonitrile is first generated, and then hydrolyzed; It can also be prepared by electrochemical fluorination of acetic acid or acetic anhydride.
 
Tfa CAS No. 76- 05-1



 

 

Organic Intermediate